enQuire Bio » Products » Antibody » Cyclin E (G1/S-Phase Cyclin) Ultraspecific Antibody Tested against >20,000 Human Proteins
Analysis of Protein Array containing more than 19,000 full-length human proteins using Cyclin E Mouse Monoclonal Antibody (CCNE1/2460). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Analysis of Protein Array containing more than 19,000 full-length human proteins using Cyclin E Mouse Monoclonal Antibody (CCNE1/2460). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.Formalin-fixed, paraffin-embedded Human Colon Carcinoma stained with Cyclin E Mouse Monoclonal Antibody (CCNE1/2460).

Cyclin E (G1/S-Phase Cyclin) Ultraspecific Antibody

Tested against >20,000 Human Proteins

$ 199.00 – $ 429.00
Please Select Product Options Below To View The Catalog Number.

SKU: 898-MSM1
Species: Human
Tested Applications: IHC
Available Conjugates: Unconjugated
Isotype: Mouse IgG, kappa
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
898-MSM1-P0 Size: 20 ug, Tag: Unconjugated $ 199.00
898-MSM1-P1 Size: 100 ug, Tag: Unconjugated $ 429.00
898-MSM1-P1ABX Size: 100 ug, Tag: Unconjugated $ 429.00
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SKU: 898-MSM1-P0
Cyclin E (G1/S-Phase Cyclin) General Information
Alternate Names
CCNE1; Cyclin E1; G1/S-specific cyclin-E1
Molecular Weight
53kDa
Chromosomal Location
Ships on blue ice.
Curated Database and Bioinformatic Data
Gene Symbol898
Entrez Gene IDCCNE1
UniProt ID(s)IDP24864
UniGene ID(s)Hs244723
COSMIC ID Link(s)CCNE1
KEGG Gene ID(s)hsa:898
General Description of Cyclin E (G1/S-Phase Cyclin).
Cyclin E belongs to the highly conserved cyclin family, whose members exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclins function as regulators of CDK kinases. Cyclin E forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Cyclin E accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Cyclin E overexpression has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis.

Human Anti-Cyclin E (G1/S-Phase Cyclin) Antibody Product Attributes

Species: Human
Tested Applications: IHC.
Clonality: Monoclonal
Anti-Cyclin E (G1/S-Phase Cyclin) Antibody Clone: CCNE1/2460
Clone CCNE1/2460 Host and Isotype: Mouse IgG, kappa
Anti-Human Cyclin E (G1/S-Phase Cyclin) Positive Control Sample: HeLa Cells. Breast or Colon Carcinoma
Cellular Localization of Antibody CCNE1/2460 Staining: Nuclear
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant human Cyclin E (CCNE1) protein fragment (apprx. aa 10-176) (Please call for additional information.)
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.

Cyclin E (G1/S-Phase Cyclin) Previously Observed Antibody Staining Patterns

Limitations and Warranty

enQuire Bio's product, Cyclin E (G1/S-Phase Cyclin) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.

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Cyclin E (G1/S-Phase Cyclin) Ultraspecific Antibody

Tested against >20,000 Human Proteins

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