Analysis of Protein Array containing more than 19,000 full-length human proteins using GP2 Mouse Monoclonal Antibody (GP2/1803) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.  A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Analysis of Protein Array containing more than 19,000 full-length human proteins using GP2 Mouse Monoclonal Antibody (GP2/1803) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.  A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.SDS-PAGE Analysis Purified GP2 Mouse Monoclonal Antibody (GP2/1803). Confirmation of Integrity and Purity of Antibody.

GP2 (Glycoprotein 2) / ZAP75 Ultraspecific Antibody

Tested against >20,000 Human Proteins

$ 228.00$ 488.00
Please Select Product Options Below To View The Catalog Number.

SKU: 2813-MSM3
Species: Human
Tested Applications: ELISA, IHC
Available Conjugates: Unconjugated
Isotype: Mouse IgG2a, kappa
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
2813-MSM3-P0 Size: 20 ug, Tag: Unconjugated $ 228.00
2813-MSM3-P1 Size: 100 ug, Tag: Unconjugated $ 488.00
2813-MSM3-P1ABX Size: 100 ug, Tag: Unconjugated $ 488.00
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SKU: 2813-MSM3-P0
GP2 (Glycoprotein 2) / ZAP75 General Information
Alternate Names
Glycoprotein 2 (zymogen granule membrane); GP2; Pancreatic zymogen granule membrane associated protein GP2; Pancreatic zymogen granule membrane protein GP-2; ZAP75
Molecular Weight
59kDa
Chromosomal Location
Ships on blue ice.
Curated Database and Bioinformatic Data
Gene Symbol2813
Entrez Gene IDGP2
UniProt ID(s)P55259
UniGene ID(s)Hs53985
COSMIC ID Link(s)GP2
KEGG Gene ID(s)hsa:2813
General Description of GP2 (Glycoprotein 2) / ZAP75.
GP2 (glycoprotein 2), also known as ZAP75, is a 537 amino acid secreted protein. It is an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. GP2 is cleaved and then released into the pancreatic duct along with exocrine secretions. GP2 binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). GP2 is also expressed on the apical plasma membrane of specialized microfold (M) cells among enterocytes and serves as a transcytotic receptor for mucosal antigens. M cells are considered a promising target for oral vaccination against various infectious diseases.

Human Anti-GP2 (Glycoprotein 2) / ZAP75 Antibody Product Attributes

Species: Human
Tested Applications: ELISA, IHC.
Clonality: Monoclonal
Anti-GP2 (Glycoprotein 2) / ZAP75 Antibody Clone: GP2/1803
Clone GP2/1803 Host and Isotype: Mouse IgG2a, kappa
Anti-Human GP2 (Glycoprotein 2) / ZAP75 Positive Control Sample: PANC-1 Cells. Pancreas
Cellular Localization of Antibody GP2/1803 Staining: Cell Surface and Secreted
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant fragment of human GP2 protein (apprx. aa 35-179) (Please call for additional information.)
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.

GP2 (Glycoprotein 2) / ZAP75 Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in GP2 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in exocrine glandular cells in the pancreas. More moderate antibody staining intensity was present in exocrine glandular cells in the pancreas. Low, but measureable presence of GP2 could be seen in. We were unable to detect GP2 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of GP2 expression as measured by anti-GP2 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity - - - + - - - - - - - - - - - - - - - -
GP2 Variability ++ + + ++ + + + + + + + + + + + + ++ + + +

Limitations and Warranty

enQuire Bio's product, GP2 (Glycoprotein 2) / ZAP75 MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.

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Tested against >20,000 Human Proteins

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GP2 (Glycoprotein 2) / ZAP75 Ultraspecific Antibody

Tested against >20,000 Human Proteins

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