Analysis of Protein Array containing more than 19,000 full-length human proteins using IgG4 Recombinant Rabbit Monoclonal Antibody (IGHG4/2042R). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.  A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Analysis of Protein Array containing more than 19,000 full-length human proteins using IgG4 Recombinant Rabbit Monoclonal Antibody (IGHG4/2042R). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.  A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.SDS-PAGE Analysis Purified IgG4 Rabbit Recombinant Monoclonal Antibody (IGHG4/2042R).

IgG4 (Ig Heavy Constant Gamma 4) Ultraspecific Antibody

Tested against >20,000 Human Proteins

$ 158.00$ 348.00
Please Select Product Options Below To View The Catalog Number.

SKU: 3503-RBM2
Species: Human
Tested Applications: IHC
Available Conjugates: Unconjugated
Isotype: Rabbit IgG
Mass Spec Validated?: Not MS Validated

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Shipping Information
In Stock: 1-2 Day Lead Time.
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
SKU: 3503-RBM2-P0
IgG4 (Ig Heavy Constant Gamma 4) (G4m Marker) General Information
Alternate Names
Ig gamma 4 chain C region; IGHG4; Immunoglobulin heavy constant gamma 4 (G4m marker)
Molecular Weight
150kDa
Chromosomal Location
Ships on blue ice.
Curated Database and Bioinformatic Data
Gene Symbol 3503
Entrez Gene ID IGHG4
UniProt ID(s) P01861
UniGene ID(s) Hs510635
COSMIC ID Link(s) IGHG4
KEGG Gene ID(s) hsa:3503
General Description of IgG4 (Ig Heavy Constant Gamma 4) (G4m Marker).
The regions of relatively constant sequence beyond the variable regions of immunoglobulins are termed constant regions (C regions) and are present in both the heavy and light chains. With very few exceptions, the sites of attachment for carbohydrates on immunoglobulins are located in these C regions. These regions also function to hold the variable regions together by using the disulfide bond between them. The C regions facilitate interaction with the antigen by increasing the maximum rotation of the immunoglobulin arms. Reportedly, a large population of patients with recurrent respiratory tract infection has low IgG4 concentrations. IgG4-related sclerosing disease has been recognized as a systemic disease entity characterized by an elevated serum IgG4 level, sclerosing fibrosis, and diffuse lympho-plasmacytic infiltration with the presence of many IgG4-positive plasma cells. IgG4 is overexpressed in inflammatory pseudo-tumor (IPT) and under expressed in inflammatory myofibroblastic tumor (IMT). In pulmonary nodular lymphoid hyperplasia (PNLH), there are an increased number of IgG4+ plasma cells.

Human Anti-IgG4 (Ig Heavy Constant Gamma 4) (G4m Marker) Antibody Product Attributes

Species: Human
Tested Applications: IHC.
Clonality: Monoclonal
Anti-IgG4 (Ig Heavy Constant Gamma 4) (G4m Marker) Antibody Clone: IGHG4/2042R
Clone IGHG4/2042R Host and Isotype: Rabbit IgG
Anti-Human IgG4 (Ig Heavy Constant Gamma 4) (G4m Marker) Positive Control Sample: Tonsil
Cellular Localization of Antibody IGHG4/2042R Staining: Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A column purification.
Immunogen: Recombinant full-length human IGHG4 protein
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.

IgG4 (Ig Heavy Constant Gamma 4) (G4m Marker) Previously Observed Antibody Staining Patterns

Limitations and Warranty

enQuire Bio's product, IgG4 (Ig Heavy Constant Gamma 4) (G4m Marker) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.

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Tested against >20,000 Human Proteins

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IgG4 (Ig Heavy Constant Gamma 4) Ultraspecific Antibody

Tested against >20,000 Human Proteins

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