Formalin-fixed, paraffin-embedded human Adrenal Gland stained with NGFR Mouse Monoclonal Antibody (NGFR/1964).

SDS-PAGE Analysis Purified NGFR Mouse Monoclonal Antibody (NGFR/1964).Confirmation of Purity and Integrity of Antibody.

Analysis of Protein Array containing more than 19,000 full-length human proteins using NGFR Mouse Monoclonal Antibody (NGFR/1964). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SDs) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SDs) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with NGFR Mouse Monoclonal Antibody (NGFR/1964).

NGF-Receptor (p75) / CD271 (Soft Tissue Tumor Marker) Ultraspecific Antibody
Tested against >20,000 Human Proteins

Name: NGF-Receptor (p75) / CD271 (Soft Tissue Tumor Marker) Ultraspecific Antibody <p style="font-size:small">Tested against &gt;20,000 Human Proteins</p>
SKU: 4804-MSM4-P0
Availability: InStock

$ 199.00 – $ 429.00

Please Select Product Options Below To View The Catalog Number.

SKU: 4804-MSM4
Species: Human
Tested Applications: IHC
Available Conjugates: Unconjugated
Isotype: Mouse IgG2b, kappa
Mass Spec Validated?: Not MS Validated

Product Number	Description	Price
4804-MSM4-P0	Size: 20 ug, Tag: Unconjugated	$ 228.00
4804-MSM4-P1	Size: 100 ug, Tag: Unconjugated	$ 488.00
4804-MSM4-P1ABX	Size: 100 ug, Tag: Unconjugated	$ 488.00

Shipping Information

In Stock.

Flat Rate Shipping Anywhere in the US: $45

Datasheets and Documentation

Product Datasheet

Certificate of Analysis and Tags (Coming Soon)

SKU: 4804-MSM4-P0

NGF-Receptor (p75) / CD271 (Soft Tissue Tumor Marker) General Information
Alternate Names
CD271; Gp80-LNGFR; Low affinity nerve growth factor receptor; Low affinity neurotrophin receptor p75NTR; Nerve growth factor receptor (NGFR); p75 ICD; p75 Neurotrophin receptor; Tumor necrosis factor receptor superfamily member 16 (TNFRSF16)
Molecular Weight
75kDa
Chromosomal Location
Ships on blue ice.
Curated Database and Bioinformatic Data
Gene Symbol	4804
Entrez Gene ID	NGFR
UniProt ID(s)	P08138
UniGene ID(s)	Hs415768 & 681726
COSMIC ID Link(s)	NGFR
KEGG Gene ID(s)	hsa:4804
General Description of NGF-Receptor (p75) / CD271 (Soft Tissue Tumor Marker).
It recognizes a glycoprotein of 75kDa, identified as low affinity Nerve Growth Factor (NGF) Receptor (p75NGFR) or Neurotrophin Receptor (p75NTR). NGFR is expressed in various neural crest cells and their tumors such as melanocytes, melanomas, neuroblastomas, pheochromocytomas and neurofibromas. Reportedly, anti-NGFR is a reliable marker for desmoplastic and neurotropic melanomas. NGFR is expressed in mature non-neural cells such as perivascular cells, dental pulp cells, lymphoidal follicular dendritic cells, basal epithelium of oral mucosa and hair follicles, prostate basal cells, and myoepithelial cells. Anti-NGFR stains the myoepithelial cells of breast ducts and intra-lobular fibroblasts of breast ducts.

Human Anti-NGF-Receptor (p75) / CD271 (Soft Tissue Tumor Marker) Antibody Product Attributes

Species: Human

Tested Applications: IHC.

Clonality: Monoclonal

Anti-NGF-Receptor (p75) / CD271 (Soft Tissue Tumor Marker) Antibody Clone: NGFR/1964

Clone NGFR/1964 Host and Isotype: Mouse IgG2b, kappa

Anti-Human NGF-Receptor (p75) / CD271 (Soft Tissue Tumor Marker) Positive Control Sample: Neuronal axons, Schwann cells, and perineural cells of peripheral nerves, or tumors of nerve sheath differentiation e.g. Schwannoma, Neurofibroma. Soma and axons of sensory neurons, and ganglionic satellite cells. Melanomas.

Cellular Localization of Antibody NGFR/1964 Staining: Cell surface and cytoplasmic

Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.

Antibody Concentration: 200 ug/ml

Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.

Immunogen: Recombinant fragment of human p75 NGFR protein (apprx. aa 281-421) (Please call for additional information.)

Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.

NGF-Receptor (p75) / CD271 (Soft Tissue Tumor Marker) Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-NGFR antibody staining is expected to be primarily localized to the nucleoplasm and plasma membrane.

Observed Antibody Staining Data By Tissue Type:

Variations in NGF-Receptor / CD271 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in peripheral nerve/ganglion in colon. More moderate antibody staining intensity was present in peripheral nerve/ganglion in colon. Low, but measureable presence of NGF-Receptor / CD271 could be seen inrespiratory epithelial cells in the bronchus, squamous epithelial cells in the cervix, uterine and esophagus, glandular cells in the gallbladder, respiratory epithelial cells in the nasopharynx, squamous epithelial cells in the oral mucosa, keratinocytes in skin and squamous epithelial cells in the tonsil. We were unable to detect NGF-Receptor / CD271 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of NGF-Receptor / CD271 expression as measured by anti-NGF-Receptor / CD271 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type	breast cancer	carcinoid	cervical cancer	colorectal cancer	endometrial cancer	glioma	head and neck cancer	liver cancer	lung cancer	lymphoma	melanoma	ovarian cancer	pancreatic cancer	prostate cancer	renal cancer	skin cancer	stomach cancer	testicular cancer	thyroid cancer	urothelial cancer
Signal Intensity	-	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NGFR Variability	+	++	+	+	+	++	++	+	+	++	+	+	+	+	+	++	+	+	+	++

Limitations and Warranty

enQuire Bio's product, NGF-Receptor (p75) / CD271 (Soft Tissue Tumor Marker) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.

There are no reviews yet.

Be the first to review “NGF-Receptor (p75) / CD271 (Soft Tissue Tumor Marker) Ultraspecific Antibody
Tested against >20,000 Human Proteins
” Cancel reply

Share a Protocol (View Reviewed Protocols Below)

Protocol Title

Tested against >20,000 Human Proteins

), and application (e.g. IHC, Flow Cytometry, Western Blot) in your title."/>

Materials

Methods

Notes

Please type the code above.

Alert me when someone comments on my protocol.

NGF-Receptor (p75) / CD271 (Soft Tissue Tumor Marker) Ultraspecific Antibody Tested against >20,000 Human Proteins