enQuire Bio » Products » Antibody » Nucleophosmin (Acute Myeloid Leukemia Marker) Ultraspecific Antibody Tested against >20,000 Human Proteins
Analysis of Protein Array containing more than 19,000 full-length human proteins using Nucleophosmin Mouse Monoclonal Antibody (NA24).Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Analysis of Protein Array containing more than 19,000 full-length human proteins using Nucleophosmin Mouse Monoclonal Antibody (NA24).Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.SDS-PAGE Analysis Purified Nucleophosmin Mouse Monoclonal Antibody (NA24).Confirmation of Integrity and Purity of Antibody.

Nucleophosmin (Acute Myeloid Leukemia Marker) Ultraspecific Antibody

Tested against >20,000 Human Proteins

$ 199.00 – $ 429.00
Please Select Product Options Below To View The Catalog Number.

SKU: 4869-MSM3
Species: Human
Tested Applications: IHC
Available Conjugates: Unconjugated
Isotype: Mouse IgG1, kappa
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
4869-MSM3-P0 Size: 20 ug, Tag: Unconjugated $ 199.00
4869-MSM3-P1 Size: 100 ug, Tag: Unconjugated $ 429.00
4869-MSM3-P1ABX Size: 100 ug, Tag: Unconjugated $ 429.00
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SKU: 4869-MSM3-P0
Nucleophosmin (Acute Myeloid Leukemia Marker) General Information
Alternate Names
NO38; NPM; NPM1; Nucleolar phosphoprotein B23; Nucleolar protein NO38; Nucleophosmin (nucleolar phosphoprotein B23 numatrin); Nucleophosmin; Nucleophosmin/nucleoplasmin family member 1; Numatrin
Molecular Weight
33kDa
Chromosomal Location
Ships on blue ice.
Curated Database and Bioinformatic Data
Gene Symbol4869
Entrez Gene IDNPM1
UniProt ID(s)P06748
UniGene ID(s)Hs557550
COSMIC ID Link(s)NPM1
KEGG Gene ID(s)hsa:4869
General Description of Nucleophosmin (Acute Myeloid Leukemia Marker).
Recognizes a 33kDa glycoprotein, identified as Nucleophosmin (NPM). It is predominantly localized in the nucleus of cells in most tissues. NPM is involved in ribosomal assembly and rRNA transport. It is an abundant protein that is highly phosphorylated by Cdc2 kinase during mitosis. This phosphoprotein moves between the nucleus and the cytoplasm. It is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in exon 12 affecting the C-terminus of the protein are associated with an aberrant cytoplasmic location. Mutations in this gene are associated with acute myeloid leukemia. The antibody may be a useful aid for classification of acute myeloid leukemia.

Human Anti-Nucleophosmin (Acute Myeloid Leukemia Marker) Antibody Product Attributes

Species: Human
Tested Applications: IHC.
Clonality: Monoclonal
Anti-Nucleophosmin (Acute Myeloid Leukemia Marker) Antibody Clone: NA24
Clone NA24 Host and Isotype: Mouse IgG1, kappa
Anti-Human Nucleophosmin (Acute Myeloid Leukemia Marker) Positive Control Sample: MCF-7, HeLa or A431 cells. Skin, Colon
Cellular Localization of Antibody NA24 Staining: Nuclear and Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: GST fusion protein containing the N-terminal part of nucleophosmin fused to 14 amino acid of ALK protein
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.

Nucleophosmin (Acute Myeloid Leukemia Marker) Previously Observed Antibody Staining Patterns

Limitations and Warranty

enQuire Bio's product, Nucleophosmin (Acute Myeloid Leukemia Marker) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.

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Nucleophosmin (Acute Myeloid Leukemia Marker) Ultraspecific Antibody

Tested against >20,000 Human Proteins

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