SDS-PAGE Analysis Purified p53 Mouse Monoclonal Antibody (TP53/1739).Confirmation of Purity and Integrity of Antibody.
SDS-PAGE Analysis Purified p53 Mouse Monoclonal Antibody (TP53/1739).Confirmation of Purity and Integrity of Antibody.Western Blot Analysis of human HeLa Cell Lysate using p53 Mouse Monoclonal Antibody (TP53/1739).

p53 Tumor Suppressor Protein Ultraspecific Antibody

Tested against >20,000 Human Proteins

$ 158.00$ 348.00
Please Select Product Options Below To View The Catalog Number.

SKU: 7157-MSM9
Species: Human
Tested Applications: WB, IHC
Available Conjugates: Unconjugated
Isotype: Mouse kappa
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 7157-MSM9-P0
p53 Tumor Suppressor Protein General Information
Alternate Names
Antigen NY-CO-13, BCC7, Cellular Tumor Antigen p53, LFS1, TP53, Transformation Related Protein 53 (TRP53), Tumor Protein p53, Tumor Suppressor p53
Molecular Weight
53kDa
Chromosomal Location
Ships on blue ice.
Curated Database and Bioinformatic Data
Gene Symbol7157
Entrez Gene IDTP53
UniProt ID(s)P04637
UniGene ID(s)Hs654481
COSMIC ID Link(s)TP53
KEGG Gene ID(s)hsa:7157
General Description of p53 Tumor Suppressor Protein.
The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. Recognizes a 53kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53. It is a tumor suppressor protein expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast, lung, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in many malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.

Human Anti-p53 Tumor Suppressor Protein Antibody Product Attributes

Species: Human
Tested Applications: WB, IHC.
Clonality: Monoclonal
Anti-p53 Tumor Suppressor Protein Antibody Clone: TP53/1739
Clone TP53/1739 Host and Isotype: Mouse kappa
Anti-Human p53 Tumor Suppressor Protein Positive Control Sample: MDA-MB-231 Cells. Breast or Colon carcinoma
Cellular Localization of Antibody TP53/1739 Staining: Predominantly nuclear
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant full-length human TP53 protein
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.

p53 Tumor Suppressor Protein Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Variations in p53 Tumor Suppressor Protein antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. Low, but measureable presence of p53 Tumor Suppressor Protein could be seen inglandular cells in the adrenal gland, hematopoietic cells in the bone marrow, glandular cells in the breast, respiratory epithelial cells in the bronchus, neuronal cells in the caudate nucleus, glandular cells in the cervix, uterine and endometrium, cells in the glomeruli in kidney, islets of Langerhans in pancreas, glandular cells in the parathyroid gland, decidual cells in the placenta, glandular cells in the salivary gland, fibroblasts in skin, cells in the white pulp in spleen, non-germinal center cells in the tonsil and squamous epithelial cells in the vagina. We were unable to detect p53 Tumor Suppressor Protein in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Type:

Tissues from cancer patients, for instance, have their own distinct pattern of p53 Tumor Suppressor Protein expression as measured by anti-p53 Tumor Suppressor Protein antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity - - + + - - - - + - + - ++ - - + + + - ++
TP53 Variability + + ++ ++ + ++ ++ ++ ++ ++ +++ ++ ++ + + ++ ++ ++ + +++

Limitations and Warranty

enQuire Bio's product, p53 Tumor Suppressor Protein MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.

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Tested against >20,000 Human Proteins

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p53 Tumor Suppressor Protein Ultraspecific Antibody

Tested against >20,000 Human Proteins

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