SDS-PAGE Analysis Purified SOX4 Mouse Monoclonal Antibody (SOX4/2540).Confirmation of Integrity and Purity of Antibody.
SDS-PAGE Analysis Purified SOX4 Mouse Monoclonal Antibody (SOX4/2540).Confirmation of Integrity and Purity of Antibody.Analysis of Protein Array containing more than 19,000 full-length human proteins using SOX4 Mouse Monoclonal Antibody (SOX4/2540).Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.  A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with SOX4 Mouse Monoclonal Antibody (SOX4/2540).

SOX4 (Master Regulator of Epithelial-Mesenchymal Transition) MonoSpecific Antibody

$ 199.00$ 429.00
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SKU: 6659-MSM1
Species: Human
Tested Applications: IHC
Available Conjugates: Unconjugated
Isotype: Mouse IgG2b, kappa
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 6659-MSM1-P0
SOX4 (Master Regulator of Epithelial-Mesenchymal Transition) General Information
Alternate Names
SOX; SRY (sex determining region Y) box 4; SRY box containing gene 4; SRY related HMG box gene 4; Transcription factor SOX-4
Molecular Weight
Chromosomal Location
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Curated Database and Bioinformatic Data
Gene Symbol6659
Entrez Gene IDSOX4
UniProt ID(s)Q06945
UniGene ID(s)Hs643910
KEGG Gene ID(s)hsa:6659
General Description of SOX4 (Master Regulator of Epithelial-Mesenchymal Transition).
SOX4 is a member of the SOX (SRY-related HMG-box) family of transcription factors with a critical role in embryonic development and in cell-fate determination during organogenesis of the heart, pancreas, brain, and in B and T lymphocyte differentiation. SOX4 gene expression is upregulated in many cancer types, and increased SOX4 activity contributes to cellular transformation, cell survival, and metastasis. Gene expression profiling has uncovered SOX4 with upregulated activity during TGF-β-induced epithelial-mesenchymal transition (EMT) in normal and cancerous breast epithelial cells. SOX4 is indispensable for EMT and cell survival in vitro and for primary tumor growth and metastasis in vivo. SOX4 is identified as a master regulator of EMT by governing the expression of the epigenetic modifier Ezh2.

Human Anti-SOX4 (Master Regulator of Epithelial-Mesenchymal Transition) Antibody Product Attributes

Species: Human
Tested Applications: IHC.
Clonality: Monoclonal
Anti-SOX4 (Master Regulator of Epithelial-Mesenchymal Transition) Antibody Clone: SOX4/2540
Clone SOX4/2540 Host and Isotype: Mouse IgG2b, kappa
Anti-Human SOX4 (Master Regulator of Epithelial-Mesenchymal Transition) Positive Control Sample: Breast or Colon Carcinoma
Cellular Localization of Antibody SOX4/2540 Staining: Nuclear
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant full-length human SOX4 protein
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.

SOX4 (Master Regulator of Epithelial-Mesenchymal Transition) Previously Observed Antibody Staining Patterns

Limitations and Warranty

enQuire Bio's product, SOX4 (Master Regulator of Epithelial-Mesenchymal Transition) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.

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