Analysis of Protein Array containing >19,000 full-length human proteins using  STAT6 Mouse Monoclonal Antibody (STAT6/2410) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.  A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Analysis of Protein Array containing >19,000 full-length human proteins using  STAT6 Mouse Monoclonal Antibody (STAT6/2410) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.  A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.SDS-PAGE Analysis Purified STAT6 Mouse Monoclonal Antibody (STAT6/2410).Confirmation of Integrity and Purity of Antibody.

STAT6 (Solitary Fibrous Tumor Marker) Ultraspecific Antibody

Tested against >20,000 Human Proteins

$ 159.00$ 349.00
Please Select A Product To View The SKU.

SKU: 6778-MSM1
Species: Human
Tested Applications: IHC
Available Conjugates: Unconjugated
Isotype: Mouse IgG1, kappa
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 6778-MSM1-P0
STAT6 (Solitary Fibrous Tumor Marker) General Information
Alternate Names
IL4 STAT; Interleukin 4 Induced Transcription Factor IL4 STAT; Signal transducer and activator of transcription 6; STAT interleukin4 induced; STAT6; Transcription factor IL 4 STAT
Molecular Weight
119kDa
Chromosomal Location
Ships on blue ice.
Curated Database and Bioinformatic Data
Gene Symbol6778
Entrez Gene IDSTAT6
UniProt ID(s)P42226
UniGene ID(s)Hs524518
COSMIC ID Link(s)STAT6
KEGG Gene ID(s)hsa:6778
General Description of STAT6 (Solitary Fibrous Tumor Marker).
STAT6 is a transcription factor in the Jak/STAT signal transduction pathway responsible for mediating IL-4 immune signaling. STAT6 was recently suggested to be a reliable marker to distinguish solitary fibrous tumors from other soft tissue neoplasms. Gene fusions are common in solitary fibrous tumors. Recent next generation sequencing studies demonstrated the presence of a NAB2-STAT6 fusion, formed by an intrachromosomal inversion fusing two neighboring genes on chromosome 12q13, in 55-100% of solitary fibrous tumors, regardless of tumor morphology or anatomical site. By immunohistochemistry, nuclear STAT6 expression can discriminate solitary fibrous tumors from its morphological mimics in the meninges, including meningioma, glioblastoma, gliosarcoma, haemangioblastoma, schwannoma and haemangioma. A recent study by Cheah, et al. using the rabbit monoclonal STAT6 antibody (Clone YE361) observed expression in all solitary fibrous tumors (54/54) tested, regardless of histology, anatomical site or CD34 status. Morphological mimics of solitary fibrous tumors were negative, demonstrating 100% specificity.

Human Anti-STAT6 (Solitary Fibrous Tumor Marker) Antibody Product Attributes

Species: Human
Tested Applications: IHC.
Clonality: Monoclonal
Anti-STAT6 (Solitary Fibrous Tumor Marker) Antibody Clone: STAT6/2410
Clone STAT6/2410 Host and Isotype: Mouse IgG1, kappa
Anti-Human STAT6 (Solitary Fibrous Tumor Marker) Positive Control Sample: HeLa or HepG2 cells. Kidney
Cellular Localization of Antibody STAT6/2410 Staining: Cytoplasmic & Nuclear
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant full-length human STAT6 protein
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.

STAT6 (Solitary Fibrous Tumor Marker) Previously Observed Antibody Staining Patterns

Limitations and Warranty

enQuire Bio's product, STAT6 (Solitary Fibrous Tumor Marker) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.

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Tested against >20,000 Human Proteins

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STAT6 (Solitary Fibrous Tumor Marker) Ultraspecific Antibody

Tested against >20,000 Human Proteins

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