SDS-PAGE Analysis Purified Thrombomodulin Mouse Recombinant MAb (rTHBD/1591).Confirmation of Purity and Integrity of Antibody.
SDS-PAGE Analysis Purified Thrombomodulin Mouse Recombinant MAb (rTHBD/1591).Confirmation of Purity and Integrity of Antibody.Analysis of Protein Array containing >19,000 full-length human proteins using Thrombomodulin Recombinant Mouse Monoclonal Antibody (rTHBD/1591) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.  A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.Formalin-fixed, paraffin-embedded human Placenta stained with Thrombomodulin / CD141 Monoclonal Antibody (rTHBD/1591).

Thrombomodulin / CD141 (Endothelial Cell Marker) MonoSpecific Antibody

$ 199.00$ 429.00
Please Select A Product To View The SKU.

SKU: 7056-MSM3
Species: Human
Tested Applications: ELISA, Flow, IF, WB, IHC
Available Conjugates: Unconjugated
Isotype: Mouse IgG1
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 7056-MSM3-P0
Thrombomodulin / CD141 (Endothelial Cell Marker) General Information
Alternate Names
AHUS6; BDCA3; CD141; Fetomodulin; Thbd; THPH12; THRM; Thrombomodulin (TM)
Molecular Weight
~100kDa
Chromosomal Location
Ships on blue ice.
Curated Database and Bioinformatic Data
Gene Symbol7056
Entrez Gene IDTHBD
UniProt ID(s)P07204
UniGene ID(s)Hs2030
COSMIC ID Link(s)THBD
KEGG Gene ID(s)hsa:7056
General Description of Thrombomodulin / CD141 (Endothelial Cell Marker).
It recognizes a protein of 75kDa, identified as Thrombomodulin. Thrombomodulin is a transmembrane glycoprotein with natural anticoagulant properties. It is normally expressed by a restricted number of cells, such as endothelial and mesothelial cells. In addition, synovial lining and syncytio-trophoblasts of placenta also express thrombomodulin. This protein is present in almost all of benign vascular tumors and majority of malignant vascular tumors (Kaposi s sarcoma, angiosarcoma, and epithelioid hemangioendothelioma). Hence, anti-thrombomodulin serves as a sensitive marker for lymphatic endothelial cells and their tumors. Recently, thrombomodulin antibody has been used for mesothelial cells and malignant mesotheliomas.

Human Anti-Thrombomodulin / CD141 (Endothelial Cell Marker) Antibody Product Attributes

Species: Human
Tested Applications: ELISA, Flow, IF, WB, IHC.
Clonality: Monoclonal
Anti-Thrombomodulin / CD141 (Endothelial Cell Marker) Antibody Clone: rTHBD/1591
Clone rTHBD/1591 Host and Isotype: Mouse IgG1
Anti-Human Thrombomodulin / CD141 (Endothelial Cell Marker) Positive Control Sample: THP1 Cells. Placenta, Angiosarcoma, Bladder or Cervical Carcinoma
Cellular Localization of Antibody rTHBD/1591 Staining: Cell Surface & Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant human Thrombomodulin protein fragment (apprx. aa 69-194) (Please call for additional information.)
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.

Thrombomodulin / CD141 (Endothelial Cell Marker) Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-THBD antibody staining is expected to be primarily localized to the cytosol and nucleoplasm.

Observed Antibody Staining Data By Tissue Type:

Variations in Thrombomodulin / CD141 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. Low, but measureable presence of Thrombomodulin / CD141 could be seen innon-germinal center cells in the lymph node and squamous epithelial cells in the tonsil. We were unable to detect Thrombomodulin / CD141 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of Thrombomodulin / CD141 expression as measured by anti-Thrombomodulin / CD141 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity - - ++ - - - + - - - - - - - - ++ - - - -
THBD Variability ++ ++ ++ + + + ++ + + + + + + ++ + ++ + + + ++

Limitations and Warranty

enQuire Bio's product, Thrombomodulin / CD141 (Endothelial Cell Marker) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.

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