Analysis of Protein Array containing more than 19,000 full-length human proteins using TIMP2 Mouse Monoclonal Antibody (TIMP2/2044)Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.  A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Analysis of Protein Array containing more than 19,000 full-length human proteins using TIMP2 Mouse Monoclonal Antibody (TIMP2/2044)Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.  A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.SDS-PAGE Analysis Purified TIMP2 Mouse Monoclonal Antibody (TIMP2/2044).Confirmation of Purity and Integrity of Antibody.

TIMP2 (Tissue Inhibitor of Metalloproteinase 2) MonoSpecific Antibody

$ 199.00$ 429.00
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SKU: 7077-MSM4
Species: Human
Tested Applications: IHC, ELISA
Available Conjugates: Unconjugated
Isotype: Mouse IgG1, kappa
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 7077-MSM4-P0
TIMP2 (Tissue Inhibitor of Metalloproteinase 2) General Information
Alternate Names
Metalloproteinase inhibitor 2; TIMP metallopeptidase inhibitor 2; TIMP-2; Tissue Inhibitor of Metalloproteinase 2
Molecular Weight
21kDa
Chromosomal Location
Ships on blue ice.
Curated Database and Bioinformatic Data
Gene Symbol7077
Entrez Gene IDTIMP2
UniProt ID(s)P16035
UniGene ID(s)Hs633514
COSMIC ID Link(s)TIMP2
KEGG Gene ID(s)hsa:7077
General Description of TIMP2 (Tissue Inhibitor of Metalloproteinase 2).
It recognizes a protein of 21kDa, identified as tissue inhibitor of metalloproteinases-2 (TIMP-2). It is closely related to TIMP-1 and shows the highest binding affinity to both the latent (pro) and active forms of 72kDa Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.

Human Anti-TIMP2 (Tissue Inhibitor of Metalloproteinase 2) Antibody Product Attributes

Species: Human
Tested Applications: IHC, ELISA.
Clonality: Monoclonal
Anti-TIMP2 (Tissue Inhibitor of Metalloproteinase 2) Antibody Clone: TIMP2/2044
Clone TIMP2/2044 Host and Isotype: Mouse IgG1, kappa
Anti-Human TIMP2 (Tissue Inhibitor of Metalloproteinase 2) Positive Control Sample: HeLa cells. Normal Placenta. Breast, Colon, Endometrial, Prostate or Ovarian Carcinoma.
Cellular Localization of Antibody TIMP2/2044 Staining: Cytoplasm and Cell Surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant human TIMP2 protein fragment (aa 48-220) (Please call for additional information.)
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.

TIMP2 (Tissue Inhibitor of Metalloproteinase 2) Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in TIMP2 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. Low, but measureable presence of TIMP2 could be seen inglandular cells in the appendix, hematopoietic cells in the bone marrow, glial cells in the caudate nucleus, neuronal cells in the cerebral cortex, glandular cells in the colon, peripheral nerve/ganglion in colon, glandular cells in the endometrium, squamous epithelial cells in the esophagus, glandular cells in the gallbladder, myocytes in heart muscle, neuronal cells in the hippocampus, hepatocytes in liver, pneumocytes in lung, germinal center cells in the lymph node, non-germinal center cells in the lymph node, respiratory epithelial cells in the nasopharynx, exocrine glandular cells in the pancreas, decidual cells in the placenta, glandular cells in the rectum, myocytes in skeletal muscle, Langerhans in skin, melanocytes in skin, smooth muscle cells in the smooth muscle, adipocytes in mesenchymal tissue, cells in the red pulp in spleen, glandular cells in the stomach, non-germinal center cells in the tonsil and squamous epithelial cells in the vagina. We were unable to detect TIMP2 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of TIMP2 expression as measured by anti-TIMP2 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity ++ + + + + - ++ + ++ ++ + + + ++ ++ ++ + ++ ++ ++
TIMP2 Variability ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ + + ++ ++ + ++ ++

Limitations and Warranty

enQuire Bio's product, TIMP2 (Tissue Inhibitor of Metalloproteinase 2) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.

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