Analysis of Protein Array containing >19,000 full-length human proteins using Thyroid Peroxidase Mouse Monoclonal Antibody (TPO/1922) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.  A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Analysis of Protein Array containing >19,000 full-length human proteins using Thyroid Peroxidase Mouse Monoclonal Antibody (TPO/1922) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.  A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.SDS-PAGE Analysis Purified TPO Mouse Monoclonal Antibody (TPO/1922).Confirmation of Integrity and Purity of the Antibody.

TPO (Thyroid Peroxidase) (Thyroid Marker) Ultraspecific Antibody

Tested against >20,000 Human Proteins

$ 158.00$ 348.00
Please Select Product Options Below To View The Catalog Number.

SKU: 7173-MSM2
Species: Human
Tested Applications: IHC
Available Conjugates: Unconjugated
Isotype: Mouse IgG1, kappa
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 7173-MSM2-P0
TPO (Thyroid Peroxidase) (Thyroid Marker) General Information
Alternate Names
MSA; TDH2A; Thyroid microsomal antigen; Thyroid peroxidase; Thyroperoxidase; TPO; TPX
Molecular Weight
100kDa
Chromosomal Location
Ships on blue ice.
Curated Database and Bioinformatic Data
Gene Symbol7173
Entrez Gene IDTPO
UniProt ID(s)P07202
UniGene ID(s)Hs467554
COSMIC ID Link(s)TPO
KEGG Gene ID(s)hsa:7173
General Description of TPO (Thyroid Peroxidase) (Thyroid Marker).
Thyroperoxidase (TPO) is a 933-amino acid, type I transmembrane glycoprotein that plays a key role in thyroid gland function and autoimmunity. It is present as a dimer on the apical surface of thyroid follicular cells. TPO functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Malignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. This antibody may aid in the differentiation between benign and malignant thyroid tumors.

Human Anti-TPO (Thyroid Peroxidase) (Thyroid Marker) Antibody Product Attributes

Species: Human
Tested Applications: IHC.
Clonality: Monoclonal
Anti-TPO (Thyroid Peroxidase) (Thyroid Marker) Antibody Clone: TPO/1922
Clone TPO/1922 Host and Isotype: Mouse IgG1, kappa
Anti-Human TPO (Thyroid Peroxidase) (Thyroid Marker) Positive Control Sample: Thyroid Carcinoma
Cellular Localization of Antibody TPO/1922 Staining: Cytoplasmic and Cell Surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant fragment of human TPO (apprx. aa 685-804) (Please call for additional information.)
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.

TPO (Thyroid Peroxidase) (Thyroid Marker) Previously Observed Antibody Staining Patterns

Limitations and Warranty

enQuire Bio's product, TPO (Thyroid Peroxidase) (Thyroid Marker) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.

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Tested against >20,000 Human Proteins

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TPO (Thyroid Peroxidase) (Thyroid Marker) Ultraspecific Antibody

Tested against >20,000 Human Proteins

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