Analysis of Protein Array containing more than 19,000 full-length human proteins using Tryptase Mouse Monoclonal Antibody (TPSAB1/1961).Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.  A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Analysis of Protein Array containing more than 19,000 full-length human proteins using Tryptase Mouse Monoclonal Antibody (TPSAB1/1961).Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.  A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.SDS-PAGE Analysis Purified Tryptase Mouse Monoclonal Antibody (TPSAB1/1961).Confirmation of Integrity and Purity of Antibody.

Tryptase (Mast Cell Marker) MonoSpecific Antibody

$ 199.00$ 429.00
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SKU: 7177-MSM1
Species: Human
Tested Applications: IHC
Available Conjugates: Unconjugated
Isotype: Mouse IgG1, kappa
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 7177-MSM1-P0
Tryptase (Mast Cell Marker) General Information
Alternate Names
Lung Tryptase; Mast cell alpha II Tryptase; Mast cell beta I Tryptase; Mast cell protease 7; Mast cell protease II; MCP7; Pituitary Tryptase; Skin Tryptase; TPS1; TPSAB1; TPSB1; Tryptase 1; Tryptase alpha 1; Tryptase skin
Molecular Weight
31-36kDa
Chromosomal Location
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Curated Database and Bioinformatic Data
Gene Symbol7177
Entrez Gene IDTPSAB1
UniProt ID(s)Q15661
UniGene ID(s)Hs405479
COSMIC ID Link(s)TPSAB1
KEGG Gene ID(s)hsa:7177
General Description of Tryptase (Mast Cell Marker).
Tryptases comprise a family of trypsin-like serine proteases (peptidase family S1). Tryptases are stored in mast cell secretory granules and basophils. Mast cells are connective tissue cells derived from blood-forming tissues that line arterial walls and secrete substances, which mediate inflammatory and immune responses. Tryptases are released into the extracellular environment and are resistant to all known endogenous proteinase inhibitors. This antibody reacts with mast cells distributed in skin, synovium, lung, and heart. This antibody does not bind with any other cell type. Human mast cell tryptase is considered to be an important marker of mast cell activation and is an important mediator of inflammation. Mastocytosis is a term collectively used for a group of disorders in which there is abnormal accumulation of mast cells in one or multiple organs. Anti-tryptase, combined with anti-CD2, anti-CD25, and anti-CD117, can be useful in identifying reactive mast cell hyperplasia, myelogenous neoplasms, mast cell leukemia, and mastocytosis.

Human Anti-Tryptase (Mast Cell Marker) Antibody Product Attributes

Species: Human
Tested Applications: IHC.
Clonality: Monoclonal
Anti-Tryptase (Mast Cell Marker) Antibody Clone: TPSAB1/1961
Clone TPSAB1/1961 Host and Isotype: Mouse IgG1, kappa
Anti-Human Tryptase (Mast Cell Marker) Positive Control Sample: Skin or Tonsil
Cellular Localization of Antibody TPSAB1/1961 Staining: Secreted and Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant human Tryptase protein fragment (apprx. aa 115-233) (Please call for additional information.)
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.

Tryptase (Mast Cell Marker) Previously Observed Antibody Staining Patterns

Limitations and Warranty

enQuire Bio's product, Tryptase (Mast Cell Marker) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.

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