Analysis of Protein Array containing more than 19,000 full-length human proteins using Vinculin Mouse Monoclonal Antibody (VCL/2572).Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.  A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Analysis of Protein Array containing more than 19,000 full-length human proteins using Vinculin Mouse Monoclonal Antibody (VCL/2572).Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.  A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.SDS-PAGE Analysis Purified VCL Mouse Monoclonal Antibody (VCL/2572).Confirmation of Integrity and Purity of Antibody.

Vinculin (Marker of Age-related Macular Degeneration) Ultraspecific Antibody

Tested against >20,000 Human Proteins

$ 158.00$ 348.00
Please Select Product Options Below To View The Catalog Number.

SKU: 7414-MSM1
Species: Human
Tested Applications: IHC
Available Conjugates: Unconjugated
Isotype: Mouse IgG1, kappa
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 7414-MSM1-P0
Vinculin (Marker of Age-related Macular Degeneration) General Information
Alternate Names
CMD1W; CMH15; Epididymis luminal protein 114; HEL114; Metavinculin; MV; MVCL; VCL; VINC; Vinculin
Molecular Weight
117kDa
Chromosomal Location
Ships on blue ice.
Curated Database and Bioinformatic Data
Gene Symbol7414
Entrez Gene IDVCL
UniProt ID(s)P18206
UniGene ID(s)Hs643896
COSMIC ID Link(s)VCL
KEGG Gene ID(s)hsa:7414
General Description of Vinculin (Marker of Age-related Macular Degeneration).
Focal adhesions are identified as areas within the plasma membrane of tissue culture cells that adhere tightly to the underlying substrate. In vivo, these regions are involved in the adhesion of cells to the extracellular matrix. Paxillin and vinculin are cytoskeletal, focal adhesion proteins that are components of a protein complex which links the Actin network to the plasma membrane. Vinculin binding sites have been identified on other cytoskeletal proteins, including Talin and α-Actinin. In addition, vinculin, Talin and α-Actinin each contain Actin binding sites. Expression of vinculin and Talin have been shown to be affected by the level of Actin expression. α-Actinin has been shown to link Actin to integrins in the plasma membrane through interactions with the vinculin and Talin complex or by a direct interaction with integrin.

Human Anti-Vinculin (Marker of Age-related Macular Degeneration) Antibody Product Attributes

Species: Human
Tested Applications: IHC.
Clonality: Monoclonal
Anti-Vinculin (Marker of Age-related Macular Degeneration) Antibody Clone: VCL/2572
Clone VCL/2572 Host and Isotype: Mouse IgG1, kappa
Anti-Human Vinculin (Marker of Age-related Macular Degeneration) Positive Control Sample: Human Bladder and Testis.
Cellular Localization of Antibody VCL/2572 Staining: Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant fragment of human Vinculin (VCL) protein (apprx. aa 174-322) (Please call for additional information.)
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.

Vinculin (Marker of Age-related Macular Degeneration) Previously Observed Antibody Staining Patterns

Limitations and Warranty

enQuire Bio's product, Vinculin (Marker of Age-related Macular Degeneration) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.

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Tested against >20,000 Human Proteins

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Vinculin (Marker of Age-related Macular Degeneration) Ultraspecific Antibody

Tested against >20,000 Human Proteins

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