enQuire Bio QP5363 Human BMP2 activity in Alkaline Phophatase production by ATDC-5 Cells. Competitor BMP2 from R&D Systems.

Recombinant Human BMP-2 Protein

$ 69.00 – $ 3,898.00

Please Select Product Options Below To View The Catalog Number.

SKU: QP5363
Species: Human
Applications: Bioactive
Available Tags: Untagged
Host: E. coli or HEK293
Purity: Greater than 95% as determined by SDS-PAGE.
Length (Amino Acids): 230 (A homodimer of 2 115AA chains)

Product Number	Description	Price
QP5363-2ug	Size: 2 ug, Host: E. coli, Tag: Untagged (Native Protein)	$ 69.00
QP5363-10ug	Size: 10 ug, Host: E. coli, Tag: Untagged (Native Protein)	$ 169.00
QP5363-100ug	Size: 100 ug, Host: E. coli, Tag: Untagged (Native Protein)	$ 539.00
QP5363-500ug	Size: 500 ug, Host: E. coli, Tag: Untagged (Native Protein)	$ 2,378.00
QP5363-1mg	Size: 1 mg, Host: E. coli, Tag: Untagged (Native Protein)	$ 3,898.00
QP5363-HEK-2ug	Size: 2 ug, Tag: Untagged (Native Protein)	$ 79.00
QP5363-HEK-10ug	Size: 10 ug, Tag: Untagged (Native Protein)	$ 149.00
QP5363-HEK-100ug	Size: 100 ug, Tag: Untagged (Native Protein)	$ 1,100.00

Shipping Information

Flat Rate Shipping Anywhere in the US: $45

Datasheets and Documentation

Product Datasheet

Certificate of Analysis and Tags (Coming Soon)

SKU: QP5363-10ug

Recombinant Human BMP-2 Protein General Information
Alternate Names
BMP-2, wu:fc59d09, bmp2
Curated Database and Bioinformatic Data
Gene Symbol	BMP2
Entrez Gene ID	650
Ensemble Gene ID	ENSG00000125845
RefSeq Protein Accession(s)	NP_001191.1
RefSeq mRNA Accession(s)	NM_001200.3
UniProt ID(s)	P12643
UniGene ID(s)	Hs.73853
HGNC ID(s)	HGNC:1069
COSMIC ID Link(s)	BMP2
KEGG Gene ID(s)	hsa:650
PharmGKB ID(s)	PA25379
General Description of Recombinant Human BMP-2 Protein.
Bone morphogenic protein 2 (BMP2) is a member of the bone morphogenetic protein (BMP) family and functions as a potent inducer of bone and cartilage development. BMP proteins are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. Active BMP2 consists of forming a homodimer or a heterodimer with a related BMP, such as BMP7. BMP2 signals through type I and type II receptor tyrosine kinases in conjuction with SMAD proteins to directly promote osteoblast differentiation. BMP2 is also important during cardiac development and supports epicardial cell migration. It may be etiologically linked to duseases such as fibrodysplasia (myositis) ossificans progressiva.

Human BMP-2 Bioactive Protein Product Attributes

Product Type: Bioactive Protein

Recombinant BMP-2 based upon sequence from: Human

Host: QP5363 protein expressed in E. coli or HEK293 cells (make selection above to chose the host of the protein).

Tag: Untagged

Recommended Applications: Bioactive

Application Notes: Please contact us for application specific information for QP5363.

Bioactivity Data: BioActivity: E. coli synthesized BMP-2 shows bioactivity at a concentration of 250 ng/mL in the Alkaline phosphatase activity induced in ATDC-5 cells assay. The bioactivity acceptance criteria is set at 4 x 10^3 units/mg. The more potent HEK293 derived BMP2 has a specific activity of less than 40 ng/ml in ATDC-5 cell induced alk phos activity.

Monomer or Dimer:Glycosylated Homodimer

Amino Acid Sequence: MQAKHKQRKR LKSSCKRHPL YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC VPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR

Purity: Greater than 95% as determined by SDS-PAGE.

Reconstitution Instructions: We recommend reconstitution of human BMP-2 in sterile 4mM HCl containing 0.1% endotoxin-free recombinant HSA.

Concentration of Human BMP-2 Protein: Lyophilized. Concentration determined by reconstitution volume.

Endotoxin Levels: Less than or equal to 1.00 EUs/ug as determined by the LAL method.

Buffer: Lyophilized from a sterile filtered (0.22 um) 2x PBS solution.

Storage Conditions: Store at -20C to -80C lyophilized. Guaranteed for 1 year at -80C reconstituted and 3 months at 4C reconstituted.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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