Recombinant Human GDF-8 / Myostatin / MSTN Protein

$ 69.00$ 4,898.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP5329
Species: Human
Applications: Bioactive
Available Tags: Untagged
Host: E. coli
Purity: Greater than 95% as determined by SDS-PAGE.
Length (Amino Acids): 109/218

Product NumberDescriptionPrice
QP5329-2ug Size: 2 ug, Tag: Untagged (Native Protein) $ 69.00
QP5329-10ug Size: 10 ug, Tag: Untagged (Native Protein) $ 169.00
QP5329-100ug Size: 100 ug, Tag: Untagged (Native Protein) $ 639.00
QP5329-500ug Size: 500 ug, Tag: Untagged (Native Protein) $ 2,978.00
QP5329-1mg Size: 1 mg, Tag: Untagged (Native Protein) $ 4,898.00
Shipping Information
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP5329-10ug
Recombinant Human GDF-8 / Myostatin / MSTN Protein General Information
Alternate Names
GDF-8, Myostatin, MSTN, Cmpt, Gdf8
Curated Database and Bioinformatic Data
Gene SymbolMSTN
Entrez Gene ID2660
Ensemble Gene IDENSG00000138379
RefSeq Protein Accession(s)NP_005250.1
RefSeq mRNA Accession(s)NM_005259.2
UniProt ID(s)O14793
UniGene ID(s)Hs.41565
HGNC ID(s)HGNC:4223
COSMIC ID Link(s)MSTN
KEGG Gene ID(s)hsa:2660
PharmGKB ID(s)PA162396253
General Description of Recombinant Human GDF-8 / Myostatin / MSTN Protein .
Myostatin (GDF-8), a conserved member of the TGF-beta superfamily, is an essential regulator of skeletal muscle mass and cardiac muscle development and function. Myostatin is a secreted protein that negatively regulates skeletal muscle growth by determining muscle fiber number and size. Myostatin binds one of the two activin type II receptors (ACTRIIA, ACTRIIB) to activate SMAD signaling. Myostatin also activates MAPK signaling through TAK1-MKK6 and Ras pathways. Inhibition of myostatin increases muscle mass in a number of human disease animal models, such as muscular dystrophy.

Human GDF-8 / Myostatin / MSTN Bioactive Protein Product Attributes

Product Type: Bioactive Protein
Recombinant GDF-8 / Myostatin / MSTN based upon sequence from: Human
Host: QP5329 protein expressed in E. coli.
Tag: Untagged
Recommended Applications: Bioactive
Application Notes: Please contact us for application specific information for QP5329.
Bioactivity Data: MPC-11 cell cytotoxicity significantly induced by less than 50 ng/ml which corresponds to an activity of at least 2.0 x 10^4 units/mg.
Monomer or Dimer: Dimer
Amino Acid Sequence: DFGLDCDEHS TESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGECEFV FLQKYPHTHL VHQANPRGSA GPCCTPTKMS PINMLYFNGK EQIIYGKIPA MVVDRCGCS
Purity: Greater than 95% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human GDF-8 / Myostatin / MSTN Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than or equal to 1.00 EUs/ug as determined by the LAL method.
Buffer: Sterile filtered (0.22 um) solution containing 0.1% TFA
Storage Conditions: Store at -20C to -80C lyophilized. Guaranteed for 1 year at -80C reconstituted and 3 months at 4C reconstituted.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human GDF-8 / Myostatin / MSTN Protein

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