Recombinant Human IL-17AF Protein

$ 69.00$ 4,898.00
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SKU: QP5200
Species: Human
Applications: Bioactive
Available Tags: Untagged
Host: E. coli
Purity: Greater than 95% as determined by SDS-PAGE.
Length (Amino Acids): IL-17A=137; IL-17F=134; Total=271

Product NumberDescriptionPrice
QP5200-5ug Size: 5 ug, Tag: Untagged (Native Protein) $ 69.00
QP5200-25ug Size: 25 ug, Tag: Untagged (Native Protein) $ 169.00
QP5200-100ug Size: 100 ug, Tag: Untagged (Native Protein) $ 639.00
QP5200-500ug Size: 500 ug, Tag: Untagged (Native Protein) $ 2,978.00
QP5200-1mg Size: 1 mg, Tag: Untagged (Native Protein) $ 4,898.00
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Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

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Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP5200-25ug
Recombinant Human IL-17AF Protein General Information
Alternate Names
IL17, IL17A, CTLA-8, IL-17A, CTLA8, IL-17, IL17F, IL-17F, IL-17F, ML-1, ML1, CANDF6
Curated Database and Bioinformatic Data
Gene SymbolIL17
Entrez Gene ID3605
Ensemble Gene IDENSG00000112115
RefSeq Protein Accession(s)NP_002181.1
RefSeq mRNA Accession(s)NM_002190.2
UniProt ID(s)Q16552; Q96PD4
UniGene ID(s)Hs.41724
HGNC ID(s)HGNC:5981
COSMIC ID Link(s)IL17A
KEGG Gene ID(s)hsa:3605
PharmGKB ID(s)PA29794
General Description of Recombinant Human IL-17AF Protein .
Interleukin 17AF (IL-17AF) is a heterodimer that is composed of the interleukin 17A (IL-17A) and interleukin 17F (IL-17F) members of the IL-17 family of cytokines. IL-17AF is produced by T helper 17 cells (Th17) following interleukin 23 (IL-23) stimulation. IL-17AF signals through the IL-17RA/IL-17RC receptor complex and functions to regulate inflammatory responses. IL-17AF induces chemokine and airway neutrophilia production, similar in function to IL-17A and IL-17F homodimers. In regard to these functions, IL-17AF is less active than the IL-17A homodimer and shows greater activity than the IL-17F homodimer. Human and rat IL-17AF are active on mouse cells.

Human IL-17AF Bioactive Protein Product Attributes

Product Type: Bioactive Protein
Recombinant IL-17AF based upon sequence from: Human
Host: QP5200 protein expressed in E. coli.
Tag: Untagged
Recommended Applications: Bioactive
Application Notes: Please contact us for application specific information for QP5200.
Bioactivity Data: Production of IL-6 from mouse 3T3 cells was significantly induced by less than 50 ng/ml of Human IL-17AF, or activity of at least 2.0 x 10^4 units/mg
Monomer or Dimer: Dimer
Amino Acid Sequence: IL-17A:MIV KAGITIPRNP GCPNSEDKNF PRTVMVNLNI HNRNTNTNPK RSSDYYNRST SPWNLHRNED PERYPSVIWE AKCRHLGCIN ADGNVDYHMN SVPIQQEILV LRREPPHCPN SFRLEKILVS VGCTCVTPIV HHVAIL-17F :MRKIPKVGH TFFQKPESCP PVPGGSMKLD IGIINENQRV SMSRNIESRS TSPWNYTVTW DPNRYPSEVV QAQCRNLGCI NAQGKEDISM NSVPIQQETL VVRRKHQGCS VSFQLEKVLV TVGCTCVTPV IHHVQ
Purity: Greater than 95% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human IL-17AF Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than or equal to 1.00 EUs/ug as determined by the LAL method.
Buffer: Sterile filtered (0.22 um) solution containing 0.1% TFA
Storage Conditions: Store at -20C to -80C lyophilized. Guaranteed for 1 year at -80C reconstituted and 3 months at 4C reconstituted.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human IL-17AF Protein

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