Recombinant Human CCL4 / MIP1B Protein

$ 98.00 – $ 1,838.00

Please Select Product Options Below To View The Catalog Number.

SKU: QP10227
Species: Human
Available Tags: Untagged
Host: E. coli
Purity: Greater than 97% as determined by SDS-PAGE and HPLC.
Length (Amino Acids): 69

Product Number	Description	Price
QP10227-ec-20ug	Size: 20 ug, Tag: Untagged (Native Protein)	$ 248.00
QP10227-ec-100ug	Size: 100 ug, Tag: Untagged (Native Protein)	$ 1,018.00
QP10227-ec-250ug	Size: 250 ug, Tag: Untagged (Native Protein)	$ 1,838.00
QP10227-ec-5ug	Size: 5 ug, Tag: Untagged (Native Protein)	$ 98.00

Shipping Information

7-10 days

Flat Rate Shipping Anywhere in the US: $45

Datasheets and Documentation

Product Datasheet

Certificate of Analysis and Tags (Coming Soon)

SKU: QP10227-ec-20ug

Recombinant Human CCL4 / MIP1B Protein General Information
Alternate Names
CCL4; MIP1B; ACT2; HC21; MIP1B1; AT744.1; G-26; MIP1B; SCYA4; LAG1; LAG-1; MIP-1-beta; SCYA2
Curated Database and Bioinformatic Data
Gene Symbol	CCL4
Entrez Gene ID	388372
Ensemble Gene ID	ENSG00000275302
RefSeq Protein Accession(s)	NP_002975.1
RefSeq mRNA Accession(s)	NM_002984.3, NM_207007.3
UniProt ID(s)	P13236
UniGene ID(s)	Hs.449862
HGNC ID(s)	HGNC:10630
KEGG Gene ID(s)	hsa:388372
PharmGKB ID(s)	PA35563
General Description of Recombinant Human CCL4 / MIP1B Protein.
Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.

Human CCL4 / MIP1B Bioactive Protein Product Attributes

Product Type: Bioactive Protein

Recombinant CCL4 / MIP1B based upon sequence from: Human

Host: QP10227 protein expressed in E. coli.

Tag: Untagged

Protein Construction: A DNA sequence encoding the Human CCL4 / MIP1B, was expressed in the hosts and tags indicated. Please select your host/tag option, above.

Application Notes: Please contact us for application specific information for QP10227.

Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by a cell proliferation assay using human CCR5 transfected murine BaF3 cells is less than 2.0 ng/ml, corresponding to a specific activity of > 5.0 Ã 105 IU/mg.

Full Length? Partial (see sequence information for more details).

Amino Acid Sequence: APMGSDPPTA CCFSYTARKL PRNFVVDYYE TSSLCSQPAV VFQTKRGKQV CADPSESWVQ EYVYDLELN

Purity: Greater than 97% as determined by SDS-PAGE and HPLC.

Reconstitution Instructions:

Concentration of Human CCL4 / MIP1B Protein: Lyophilized. Concentration determined by reconstitution volume.

Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.

Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized

Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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