Recombinant Human IL33 / Interleukin-33 / NF-HEV Protein

$ 98.00$ 3,188.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP10329
Species: Human
Available Tags: Untagged
Host: E. coli
Purity: Greater than 97% as determined by SDS-PAGE and HPLC.
Length (Amino Acids): 159

Product NumberDescriptionPrice
QP10329-ec-2ug Size: 2 ug, Tag: Untagged (Native Protein) $ 98.00
QP10329-ec-10ug Size: 10 ug, Tag: Untagged (Native Protein) $ 248.00
QP10329-ec-100ug Size: 100 ug, Tag: Untagged (Native Protein) $ 1,778.00
QP10329-ec-250ug Size: 250 ug, Tag: Untagged (Native Protein) $ 3,188.00
Shipping Information
7-10 days
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP10329-ec-2ug
Recombinant Human IL33 / Interleukin-33 / NF-HEV Protein Protein General Information
Alternate Names
IL33; Interleukin-33; NF-HEV Protein; NF-HEV; C9orf26; DVS27; IL1F11; NFEHEV
Curated Database and Bioinformatic Data
Gene SymbolIL33
Entrez Gene ID90865
Ensemble Gene IDENSG00000137033
RefSeq Protein Accession(s)NP_001186569.1
RefSeq mRNA Accession(s)NM_001199640.1, NM_001199641.1, NM_001314044.1, NM_001314045.1, NM_001314046.1, NM_001314047.1, NM_001314048.1, NM_033439.3
UniProt ID(s)O95760
UniGene ID(s)Hs.731660
HGNC ID(s)HGNC:16028
COSMIC ID Link(s)IL33
KEGG Gene ID(s)hsa:90865
PharmGKB ID(s)PA162392005
General Description of Recombinant Human IL33 / Interleukin-33 / NF-HEV Protein Protein.
Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528). ; In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (PubMed:21734074). This form is rapidely lost upon angiogenic or proinflammatory activation (PubMed:18787100).

Human IL33 / Interleukin-33 / NF-HEV Protein Bioactive Protein Product Attributes

Product Type: Bioactive Protein
Recombinant IL33 / Interleukin-33 / NF-HEV Protein based upon sequence from: Human
Host: QP10329 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human IL33 / Interleukin-33 / NF-HEV Protein, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10329.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by a cell proliferation assay using murine D10S cells is less than 0.05 ng/ml, corresponding to a specific activity of > 2.0 × 107 IU/mg.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: SITGISPITE YLASLSTYND QSITFALEDE SYEIYVEDLK KDEKKDKVLL SYYESQHPSN ESGDGVDGKM LMVTLSPTKD FWLHANNKEH SVELHKCEKP LPDQAFFVLH NMHSNCVSFE CKTDPGVFIG VKDNHLALIK VDSSENLCTE NILFKLSET
Purity: Greater than 97% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human IL33 / Interleukin-33 / NF-HEV Protein Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2um filtered 20 mM PBS, 150 mM NaCl, 1mM EDTA, pH7.4, lyophilized
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human IL33 / Interleukin-33 / NF-HEV Protein