Recombinant Human IL1F6 / IL36 Protein

$ 98.00$ 3,828.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP10338
Species: Human
Available Tags: Untagged
Host: E. coli
Purity: Greater than 95% as determined by SDS-PAGE and HPLC.
Length (Amino Acids): 153

Product NumberDescriptionPrice
QP10338-ec-10ug Size: 10 ug, Tag: Untagged (Native Protein) $ 248.00
QP10338-ec-100ug Size: 100 ug, Tag: Untagged (Native Protein) $ 2,128.00
QP10338-ec-250ug Size: 250 ug, Tag: Untagged (Native Protein) $ 3,828.00
QP10338-ec-2ug Size: 2 ug, Tag: Untagged (Native Protein) $ 98.00
Shipping Information
7-10 days
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP10338-ec-10ug
Recombinant Human IL1F6 / IL36 Protein General Information
Curated Database and Bioinformatic Data
Gene SymbolIl36a
Entrez Gene ID27179
Ensemble Gene IDENSG00000136694
RefSeq Protein Accession(s)NP_055255.1
RefSeq mRNA Accession(s)NM_014440.2, XM_005263639.2, XM_011510965.1, XM_017003806.1
UniProt ID(s)Q9UHA7
UniGene ID(s)Hs.278910
HGNC ID(s)HGNC:15562
COSMIC ID Link(s)Il36a
KEGG Gene ID(s)hsa:27179
PharmGKB ID(s)PA38389
General Description of Recombinant Human IL1F6 / IL36 Protein.
Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by upregulating surface expression of CD83, CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T cell proliferation. May play a role in proinflammatory effects in the lung.

Human IL1F6 / IL36 Bioactive Protein Product Attributes

Product Type: Bioactive Protein
Recombinant IL1F6 / IL36 based upon sequence from: Human
Host: QP10338 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human IL1F6 / IL36, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10338.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by inducing IL-8 secretion in human preadipocytes is less than 10 ng/ml, corresponding to a specific activity of > 1.0 × 105 IU/mg.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: KIDTPQQGSI QDINHRVWVL QDQTLIAVPR KDRMSPVTIA LISCRHVETL EKDRGNPIYL GLNGLNLCLM CAKVGDQPTL QLKEKDIMDL YNQPEPVKSF LFYHSQSGRN STFESVAFPG WFIAVSSEGG CPLILTQELG KANTTDFGLT MLF
Purity: Greater than 95% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human IL1F6 / IL36 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered 20 mM Tris, 300 mM NaCl, pH 8.0, 0.1 % Tween 80, lyophilized
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human IL1F6 / IL36 Protein