Recombinant Human IL36B / IL1F8 Protein

$ 108.00$ 3,578.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP10339
Species: Human
Available Tags: Untagged
Host: E. coli
Purity: Greater than 97% as determined by SDS-PAGE and HPLC.
Length (Amino Acids): 157

Product NumberDescriptionPrice
QP10339-ec-10ug Size: 10 ug, Tag: Untagged (Native Protein) $ 248.00
QP10339-ec-100ug Size: 100 ug, Tag: Untagged (Native Protein) $ 1,778.00
QP10339-ec-250ug Size: 250 ug, Tag: Untagged (Native Protein) $ 3,188.00
QP10339-ec-2ug Size: 2 ug, Tag: Untagged (Native Protein) $ 98.00
Shipping Information
7-10 days
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP10339-ec-10ug
Recombinant Human IL36B / IL1F8 Protein General Information
Alternate Names
IL36B; IL1F8; IL-1H2; FIL1; FIL1-(ETA); IL1-ETA; IL1H2; IL-1F8; IL1F8; FIL1H; FILI-(ETA)
Curated Database and Bioinformatic Data
Gene SymbolIl36b
Entrez Gene ID27177
Ensemble Gene IDENSG00000136696
RefSeq Protein Accession(s)NP_055253.2
RefSeq mRNA Accession(s)NM_014438.4, NM_173178.2, XM_011510962.1
UniProt ID(s)Q9NZH7
HGNC ID(s)HGNC:15564
COSMIC ID Link(s)Il36b
KEGG Gene ID(s)hsa:27177
PharmGKB ID(s)PA38391
General Description of Recombinant Human IL36B / IL1F8 Protein.
Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6.

Human IL36B / IL1F8 Bioactive Protein Product Attributes

Product Type: Bioactive Protein
Recombinant IL36B / IL1F8 based upon sequence from: Human
Host: QP10339 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human IL36B / IL1F8, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10339.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The specific activity is determined by its binding ability in a functional ELISA. Immobilized rHuIL-36beta at 1 ug/mL can bind recombinant human IL-1 Rrp2 Fc Chimera with a range of 0.15-5 ug/mL.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: MNPQREAAPK SYAIRDSRQM VWVLSGNSLI AAPLSRSIKP VTLHLIACRD TEFSDKEKGN MVYLGIKGKD LCLFCAEIQG KPTLQLKEKN IMDLYVEKKA QKPFLFFHNK EGSTSVFQSV SYPGWFIATS TTSGQPIFLT KERGITNNTN FYLDSVE
Purity: Greater than 97% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human IL36B / IL1F8 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human IL36B / IL1F8 Protein