Recombinant Human IL1F5 / IL36RN Protein

$ 98.00$ 1,838.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP10343
Species: Human
Available Tags: Untagged
Host: E. coli
Purity: Greater than 95% as determined by SDS-PAGE and HPLC.
Length (Amino Acids): 154

Product NumberDescriptionPrice
QP10343-ec-5ug Size: 5 ug, Tag: Untagged (Native Protein) $ 98.00
QP10343-ec-25ug Size: 25 ug, Tag: Untagged (Native Protein) $ 248.00
QP10343-ec-100ug Size: 100 ug, Tag: Untagged (Native Protein) $ 1,018.00
QP10343-ec-250ug Size: 250 ug, Tag: Untagged (Native Protein) $ 1,838.00
Shipping Information
7-10 days
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP10343-ec-5ug
Recombinant Human IL1F5 / IL36RN Protein General Information
Alternate Names
IL1F5; IL36RN; IL1HY1; FIL1(DELTA); PSORP; IL1RP3; IL1L1; IL36RA; FIL1; IL-36Ra; PSORS14; FIL1D; IL1F5
Curated Database and Bioinformatic Data
Gene SymbolIL36RN
Entrez Gene ID26525
Ensemble Gene IDENSG00000136695
RefSeq Protein Accession(s)NP_036407.1
RefSeq mRNA Accession(s)NM_012275.2, NM_173170.1
UniProt ID(s)Q9UBH0
UniGene ID(s)Hs.516301
HGNC ID(s)HGNC:15561
COSMIC ID Link(s)IL36RN
KEGG Gene ID(s)hsa:26525
PharmGKB ID(s)PA38388
General Description of Recombinant Human IL1F5 / IL36RN Protein.
Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.

Human IL1F5 / IL36RN Bioactive Protein Product Attributes

Product Type: Bioactive Protein
Recombinant IL1F5 / IL36RN based upon sequence from: Human
Host: QP10343 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human IL1F5 / IL36RN, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10343.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by inhibiting IL-36 beta induced IL-8 secretion by human preadipocytes is less than 1.0 ug/ml, corresponding to a specific activity of > 1000 IU/mg in the presence of 20 ng/ml of recombinant human IL-36 beta.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: VLSGALCFRM KDSALKVLYL HNNQLLAGGL HAGKVIKGEE ISVVPNRWLD ASLSPVILGV QGGSQCLSCG VGQEPTLTLE PVNIMELYLG AKESKSFTFY RRDMGLTSSF ESAAYPGWFL CTVPEADQPV RLTQLPENGG WNAPITDFYF QQCD
Purity: Greater than 95% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human IL1F5 / IL36RN Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human IL1F5 / IL36RN Protein