Recombinant Human SCF / C-kit ligand Protein

$ 98.00$ 1,468.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP10344
Species: Human
Available Tags: Untagged
Host: E. coli
Purity: Greater than 97% as determined by SDS-PAGE and HPLC.
Length (Amino Acids): 164

Product NumberDescriptionPrice
QP10344-ec-2ug Size: 2 ug, Tag: Untagged (Native Protein) $ 98.00
QP10344-ec-10ug Size: 10 ug, Tag: Untagged (Native Protein) $ 248.00
QP10344-ec-100ug Size: 100 ug, Tag: Untagged (Native Protein) $ 818.00
QP10344-ec-250ug Size: 250 ug, Tag: Untagged (Native Protein) $ 1,468.00
Shipping Information
7-10 days
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP10344-ec-2ug
Recombinant Human SCF / C-kit ligand Protein General Information
Alternate Names
SCF; C-kit ligand; FPH2; DCUA; Kitl; SHEP7; SCF; DFNA69; SF; FPHH; KL-1; MGF
Curated Database and Bioinformatic Data
Gene SymbolKitlg
Entrez Gene ID4254
Ensemble Gene IDENSG00000049130
RefSeq Protein Accession(s)NP_000890.1
RefSeq mRNA Accession(s)NM_000899.4, NM_003994.5
UniProt ID(s)P21583
UniGene ID(s)Hs.1048
HGNC ID(s)HGNC:6343
COSMIC ID Link(s)KITLG
KEGG Gene ID(s)hsa:4254
PharmGKB ID(s)PA30129
General Description of Recombinant Human SCF / C-kit ligand Protein.
Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.

Human SCF / C-kit ligand Bioactive Protein Product Attributes

Product Type: Bioactive Protein
Recombinant SCF / C-kit ligand based upon sequence from: Human
Host: QP10344 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human SCF / C-kit ligand, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10344.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 2 ng/ml, corresponding to a specific activity of > 5.0 × 105 IU/mg.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: EGICRNRVTN NVKDVTKLVA NLPKDYMITL KYVPGMDVLP SHCWISEMVV QLSDSLTDLL DKFSNISEGL SNYSIIDKLV NIVDDLVECV KENSSKDLKK SFKSPEPRLF TPEEFFRIFN RSIDAFKDFV VASETSDCVV SSTLSPEKDS RVSVTKPFML PPVA
Purity: Greater than 97% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human SCF / C-kit ligand Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human SCF / C-kit ligand Protein