Recombinant Human BLyS / TNFSF13B / BAFF Protein

$ 98.00$ 2,478.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP10357
Species: Human
Available Tags: Untagged
Host: E. coli
Purity: Greater than 95% as determined by SDS-PAGE and HPLC.
Length (Amino Acids): 153

Product NumberDescriptionPrice
QP10357-ec-5ug Size: 5 ug, Tag: Untagged (Native Protein) $ 98.00
QP10357-ec-20ug Size: 20 ug, Tag: Untagged (Native Protein) $ 248.00
QP10357-ec-100ug Size: 100 ug, Tag: Untagged (Native Protein) $ 1,158.00
QP10357-ec-250ug Size: 250 ug, Tag: Untagged (Native Protein) $ 2,478.00
Shipping Information
7-10 days
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP10357-ec-5ug
Recombinant Human BLyS / TNFSF13B / BAFF Protein General Information
Alternate Names
BLyS; TNFSF13B; BAFF; TNFSF20; DTL; THANK; ZTNF4; BLYS; CD257; TALL1; TNLG7A; BAFF; TALL-1
Curated Database and Bioinformatic Data
Gene SymbolTNFSF13B
Entrez Gene ID10673
Ensemble Gene IDENSG00000102524
RefSeq Protein Accession(s)NP_001139117.1
RefSeq mRNA Accession(s)NM_001145645.2, NM_006573.4
UniProt ID(s)Q9Y275
UniGene ID(s)Hs.525157
HGNC ID(s)HGNC:11929
COSMIC ID Link(s)TNFSF13B
KEGG Gene ID(s)hsa:10673
PharmGKB ID(s)PA434
General Description of Recombinant Human BLyS / TNFSF13B / BAFF Protein.
Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. ; Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. ; Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis.

Human BLyS / TNFSF13B / BAFF Bioactive Protein Product Attributes

Product Type: Bioactive Protein
Recombinant BLyS / TNFSF13B / BAFF based upon sequence from: Human
Host: QP10357 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human BLyS / TNFSF13B / BAFF, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10357.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by a mouse splenocyte survival assay is 0.5-2 ug/ml.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: MAVQGPEETV TQDCLQLIAD SETPTIQKGS YTFVPWLLSF KRGSALEEKE NKILVKETGY FFIYGQVLYT DKTYAMGHLI QRKKVHVFGD ELSLVTLFRC IQNMPETLPN NSCYSAGIAK LEEGDELQLA IPRENAQISL DGDVTFFGAL KLL
Purity: Greater than 95% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human BLyS / TNFSF13B / BAFF Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH7.4, with 0.02 % Tween-20, lyophilized
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human BLyS / TNFSF13B / BAFF Protein