Recombinant Human Osteoprotegerin / TNFRSF11B Protein

$ 98.00$ 918.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP10427
Species: Human
Available Tags: Untagged
Host: E. coli
Purity: Greater than 95% as determined by SDS-PAGE and HPLC.
Length (Amino Acids): 173

Product NumberDescriptionPrice
QP10427-ec-10ug Size: 10 ug, Tag: Untagged (Native Protein) $ 98.00
QP10427-ec-50ug Size: 50 ug, Tag: Untagged (Native Protein) $ 248.00
QP10427-ec-100ug Size: 100 ug, Tag: Untagged (Native Protein) $ 508.00
QP10427-ec-250ug Size: 250 ug, Tag: Untagged (Native Protein) $ 918.00
Shipping Information
7-10 days
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP10427-ec-10ug
Recombinant Human Osteoprotegerin / TNFRSF11B Protein General Information
Alternate Names
Osteoprotegerin; TNFRSF11B; PDB5; OCIF; OPG; TR1
Curated Database and Bioinformatic Data
Gene SymbolTNFRSF11B
Entrez Gene ID4982
Ensemble Gene IDENSG00000164761
RefSeq Protein Accession(s)NP_002537.3
RefSeq mRNA Accession(s)NM_002546.3
UniProt ID(s)O00300
HGNC ID(s)HGNC:11909
COSMIC ID Link(s)TNFRSF11B
KEGG Gene ID(s)hsa:4982
PharmGKB ID(s)PA36602
General Description of Recombinant Human Osteoprotegerin / TNFRSF11B Protein.
Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.

Human Osteoprotegerin / TNFRSF11B Bioactive Protein Product Attributes

Product Type: Bioactive Protein
Recombinant Osteoprotegerin / TNFRSF11B based upon sequence from: Human
Host: QP10427 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human Osteoprotegerin / TNFRSF11B, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10427.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by neutralizing the stimulation of U937 cells is less than 10 ng/ml, corresponding to a specific activity of > 1.0 × 105 IU/mg in the presence of 10 ng/mL soluble rHuRANKL (sRANKL).
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: ETFPPKYLHY DEETSHQLLC DKCPPGTYLK QHCTAKWKTV CAPCPDHYYT DSWHTSDECL YCSPVCKELQ YVKQECNRTH NRVCECKEGR YLEIEFCLKH RSCPPGFGVV QAGTPERNTV CKRCPDGFFS NETSSKAPCR KHTNCSVFGL LLTQKGNATH DNICSGNSES TQK
Purity: Greater than 95% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human Osteoprotegerin / TNFRSF11B Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered 30 % acetonitrile, 0.1 % TFA, lyophilized
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human Osteoprotegerin / TNFRSF11B Protein

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