PDF DatasheetHuman C-X-C chemokine receptor type 4 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant C-X-C chemokine receptor type 4 based upon sequence from Human
Host: QP9950 protein expressed in Invitro-E.coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) C-X-C chemokine receptor type 4, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP9950.
Bioactivity Data: Untested
Full Length? Full Length Transmembrane Protein
Expression Region: Met1 – Ser352
Amino Acid Sequence: MEGISIYTSD NYTEEMGSGD YDSMKEPCFR EENANFNKIF LPTIYSIIFL TGIVGNGLVI LVMGYQKKLR SMTDKYRLHL SVADLLFVIT LPFWAVDAVA NWYFGNFLCK AVHVIYTVNL YSSVLILAFI SLDRYLAIVH ATNSQRPRKL LAEKVVYVGV WIPALLLTIP DFIFANVSEA DDRYICDRFY PNDLWVVVFQ FQHIMVGLIL PGIVILSCYC IIISKLSHSK GHQKRKALKT TVILILAFFA CWLPYYIGIS IDSFILLEII KQGCEFENTV HKWISITEAL AFFHCCLNPI LYAFLGAKFK TSAQHALTSV SRGSSLKILS KGKRGGHSSV STESESSSFH SS
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human C-X-C chemokine receptor type 4 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human C-X-C chemokine receptor type 4 Protein General Information | |
|---|---|
| Alternate Names | |
| HSY3RR; FB22; HM89; LAP-3; NPYY3R; WHIM; CD184; LAP3; LESTR; WHIMS; D2S201E; NPY3R; NPYRL; LCR1; NPYR | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CXCR4 |
| Entrez Gene ID | 7852 |
| Ensemble Gene ID | ENSG00000121966 |
| RefSeq Protein Accession(s) | NP_001008540.1 |
| RefSeq mRNA Accession(s) | NM_001008540.2, NM_001348056.1, NM_001348059.1, NM_001348060.1, NM_003467.2 |
| UniProt ID(s) | P61073 |
| UniGene ID(s) | Hs.593413 |
| HGNC ID(s) | HGNC:2561 |
| COSMIC ID Link(s) | CXCR4 |
| KEGG Gene ID(s) | hsa:7852 |
| PharmGKB ID(s) | PA27058 |
| General Description of Recombinant Human C-X-C chemokine receptor type 4 Protein. | |
| Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival.10 Publications (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) for human immunodeficiency virus-1/HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus (PubMed:9427609, PubMed:10074122, PubMed:10756055). Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205) |
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Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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