Placeholder

Recombinant Human Protein cereblon Protein

$ 1,388.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP10011
Species: Human
Available Tags: His
Host: Invitro-E.coli
Purity: Greater than 80% as determined by SDS-PAGE.
Length (Amino Acids): 442

Product NumberDescriptionPrice
QP10011-iv-100ug Size: 100 ug, Tag: His
Shipping Information
On Demand Protein: 3-5 Week Lead Time. (Why?)
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP10011-iv-10ug
Recombinant Human Protein cereblon Protein General Information
Alternate Names
MRT2; MRT2A
Curated Database and Bioinformatic Data
Gene SymbolCrbn
Entrez Gene ID51185
Ensemble Gene IDENSG00000113851
RefSeq Protein Accession(s)NP_001166953.1
RefSeq mRNA Accession(s)NM_001173482.1, NM_016302.3
UniProt ID(s)Q96SW2
UniGene ID(s)Hs.18925
HGNC ID(s)HGNC:30185
COSMIC ID Link(s)Crbn
KEGG Gene ID(s)hsa:51185
PharmGKB ID(s)PA134926851
General Description of Recombinant Human Protein cereblon Protein.
Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3

Human Protein cereblon Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant Protein cereblon based upon sequence from: Human
Host: QP10011 protein expressed in Invitro-E.coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens(Human) Protein cereblon, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10011.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 - Leu442
Amino Acid Sequence: MAGEGDQQDA AHNMGNHLPL LPAESEEEDE MEVEDQDSKE AKKPNIINFD TSLPTSHTYL GADMEEFHGR TLHDDDSCQV IPVLPQVMMI LIPGQTLPLQ LFHPQEVSMV RNLIQKDRTF AVLAYSNVQE REAQFGTTAE IYAYREEQDF GIEIVKVKAI GRQRFKVLEL RTQSDGIQQA KVQILPECVL PSTMSAVQLE SLNKCQIFPS KPVSREDQCS YKWWQKYQKR KFHCANLTSW PRWLYSLYDA ETLMDRIKKQ LREWDENLKD DSLPSNPIDF SYRVAACLPI DDVLRIQLLK IGSAIQRLRC ELDIMNKCTS LCCKQCQETE ITTKNEIFSL SLCGPMAAYV NPHGYVHETL TVYKACNLNL IGRPSTEHSW FPGYAWTVAQ CKICASHIGW KFTATKKDMS PQKFWGLTRS ALLPTIPDTE DEISPDKVIL CL
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Protein cereblon Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

There are no reviews yet.

Be the first to review “Recombinant Human Protein cereblon Protein”

Your email address will not be published. Required fields are marked *

Share a Protocol (View Reviewed Protocols Below)

Protocol Title

Materials

Methods

Notes


  protocol submission gif
enQuire Bio, LLC   8420 S Continental Divide Rd, #202   Littleton, CO 80127
Chat: See lower right corner. | enquire@enquirebio.com | Fax: 1-720-897-3730
Customer Service Available M-F 8AM-6PM MST or 24/7 Via Email

Recombinant Human Protein cereblon Protein