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Recombinant Human Survivin / BIRC5 / API4 Protein

$ 448.00$ 1,938.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP5719
Species: Human
Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Available Tags: His-SUMO
Host: E. coli
Purity: Greater than 80% as determined by SDS-PAGE.
Length (Amino Acids): 143

Product NumberDescriptionPrice
QP5719-ec-100ug Size: 100 ug, Tag: His-SUMO $ 398.00
QP5719-ec-1mg Size: 1 mg, Tag: His-SUMO $ 1,728.00
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1-2 weeks
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
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Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

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Bioactivity (test results eg. IU/ml):


SKU: QP5719-ec-10ug
Recombinant Human Survivin / BIRC5 / API4 Protein General Information
Curated Database and Bioinformatic Data
Gene SymbolBIRC5
Entrez Gene ID332
Ensemble Gene IDENSG00000089685
RefSeq Protein Accession(s)NP_001012270.1
RefSeq mRNA Accession(s)NM_001012270.1, NM_001012271.1, NM_001168.2
UniProt ID(s)O15392
UniGene ID(s)Hs.744872
HGNC ID(s)HGNC:593
COSMIC ID Link(s)BIRC5
KEGG Gene ID(s)hsa:332
PharmGKB ID(s)PA25362
General Description of Recombinant Human Survivin / BIRC5 / API4 Protein.
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.

Human Survivin / BIRC5 / API4 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant Survivin / BIRC5 / API4 based upon sequence from Human
Host: QP5719 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Survivin / BIRC5 / API4, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5719.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 - Asp142
Amino Acid Sequence: MGAPTLPPAW QPFLkDaHRI STFKNWPFLE GCACTPERMA EAGFIHCPTE NEPDLAQCFF CFKELEGWEP DDDPIEEHKK HSSGCAFLSV KKQFEELTLG EFLKLDRERA KNKIAKETNN KKKEFEETAK KVRRAIEQLA AMD
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Survivin / BIRC5 / API4 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human Survivin / BIRC5 / API4 Protein