SDS-PAGE separation of QP5737 followed by commassie total protein stain results in a primary band consistent with reported data for C5a / Complement 5a. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Human C5a / Complement 5a Protein

$ 398.00 – $ 1,728.00

Please Select Product Options Below To View The Catalog Number.

SKU: QP5737
Species: Human
Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Available Tags: His, His-SUMO
Host: E.coli, Mammal.
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 74

Product Number	Description	Price
QP5737-ma-20ug	Size: 20 ug, Tag: His	$ 438.00
QP5737-ma-100ug	Size: 100 ug, Tag: His	$ 1,228.00
QP5737-ec-100ug	Size: 100 ug, Tag: His-SUMO	$ 398.00
QP5737-ec-1mg	Size: 1 mg, Tag: His-SUMO	$ 1,728.00

Shipping Information

3-4 weeks

Flat Rate Shipping Anywhere in the US: $45

Datasheets and Documentation

Product Datasheet

Certificate of Analysis and Tags (Coming Soon)

SKU: QP5737-ma-20ug

Recombinant Human C5a / Complement 5a Protein General Information
Alternate Names
C5a, Complement 5a, C5a, ECLZB, C5D, CPAMD4, C5b
Curated Database and Bioinformatic Data
Gene Symbol	C5
Entrez Gene ID	727
Ensemble Gene ID	ENSG00000106804
RefSeq Protein Accession(s)	NP_001304092.1
RefSeq mRNA Accession(s)	NM_001317163.1, NM_001735.2
UniProt ID(s)	P01031
UniGene ID(s)	Hs.494997
HGNC ID(s)	HGNC:1331
COSMIC ID Link(s)	C5
KEGG Gene ID(s)	hsa:727
PharmGKB ID(s)	PA25911
General Description of Recombinant Human C5a / Complement 5a Protein.
Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes (PubMed:8182049). C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.

Human C5a / Complement 5a Recombinant Protein Product Attributes

Product Type: Recombinant Protein

Recombinant C5a / Complement 5a based upon sequence from Human

Host: QP5737 protein expressed in E.coli, Mammal..

Tag: His

Protein Construction: A DNA sequence encoding the Homo sapiens (Human) C5a / Complement 5a, was expressed in the hosts and tags indicated. Please select your host/tag option, above.

Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.

Application Notes: Please contact us for application specific information for QP5737.

Bioactivity Data: Untested

Full Length? Partial (see sequence information for more details).

Expression Region: Thr678 - Arg751

Amino Acid Sequence: TLQKKIEEIA AKYKHSVVKK CCYDGACVNN DETCEQRAAR ISLGPRCIKA FTECCVVASQ LRANISHKDM QLGR

Purity: Greater than 90% as determined by SDS-PAGE.

Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.

Concentration of Human C5a / Complement 5a Protein:

Endotoxin Levels: Not determined.

Buffer: Tris-based buffer, 50% glycerol

Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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