SDS-PAGE separation of QP5852 followed by commassie total protein stain results in a primary band consistent with reported data for Collagen alpha-1(IV) chain. These data demonstrate Greater than 90% as determined by SDS-PAGE.
SDS-PAGE separation of QP5852 followed by commassie total protein stain results in a primary band consistent with reported data for Collagen alpha-1(IV) chain. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Human Collagen alpha-1(IV) chain Protein

$ 398.00$ 1,728.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP5852
Species: Human
Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Available Tags: His-SUMO
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 225

Product NumberDescriptionPrice
QP5852-ec-100ug Size: 100 ug, Tag: His-SUMO $ 398.00
QP5852-ec-1mg Size: 1 mg, Tag: His-SUMO $ 1,728.00
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2-4 weeks
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Datasheets and Documentation
Product Datasheet
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SKU: QP5852-ec-10ug
Recombinant Human Collagen alpha-1(IV) chain Protein (1445-1669aa) General Information
Alternate Names
BSVD, RATOR
Curated Database and Bioinformatic Data
Gene SymbolCOL4A1
Entrez Gene ID1282
Ensemble Gene IDENSG00000187498
RefSeq Protein Accession(s)NP_001290039.1
RefSeq mRNA Accession(s)NM_001303110.1, NM_001845.5
UniProt ID(s)P02462
UniGene ID(s)Hs.17441
HGNC ID(s)HGNC:2202
COSMIC ID Link(s)COL4A1
KEGG Gene ID(s)hsa:1282
PharmGKB ID(s)PA26717
General Description of Recombinant Human Collagen alpha-1(IV) chain Protein (1445-1669aa).
Type IV collagen is the major structural component of glomerular basent mbranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin.

Human Collagen alpha-1(IV) chain Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant Collagen alpha-1(IV) chain based upon sequence from Human
Host: QP5852 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Collagen alpha-1(IV) chain, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5852.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Gly1445 - Thr1669
Amino Acid Sequence: GFLVTRHSQT IDDPQCPSGT KILYHGYSLL YVQGNERAHG QDLGTAGSCL RKFSTMPFLF CNINNVCNFA SRNDYSYWLS TPEPMPMSMA PITGENIRPF ISRCAVCEAP AMVMAVHSQT IQIPPCPSGW SSLWIGYSFV MHTSAGAEGS GQALASPGSC LEEFRSAPFI ECHGRGTCNY YANAYSFWLA TIERSEMFKK PTPSTLKAGE LRTHVSRCQV CMRRT
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Collagen alpha-1(IV) chain Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human Collagen alpha-1(IV) chain Protein

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