SEQUEST analysis of LC MS/MS spectra obtained from a run with QP6020 identified a match between this protein and the spectra of a peptide sequence that matches a region of FAP / Seprase.

Additional SEQUEST analysis of the LC MS/MS spectra from QP6020 identified an additional between this protein and the spectra of another peptide sequence that matches a region of FAP / Seprase confirming successful recombinant synthesis.

Recombinant Human FAP / Seprase Protein

$ 398.00 – $ 1,728.00

Please Select Product Options Below To View The Catalog Number.

SKU: QP6020
Species: Human
Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Available Tags: GST
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 735

Product Number	Description	Price
QP6020-ec-100ug	Size: 100 ug, Tag: GST	$ 398.00
QP6020-ec-1mg	Size: 1 mg, Tag: GST	$ 1,728.00

Shipping Information

2-4 weeks

Flat Rate Shipping Anywhere in the US: $45

Datasheets and Documentation

Product Datasheet

Certificate of Analysis and Tags (Coming Soon)

SKU: QP6020-ec-10ug

Recombinant Human FAP / Seprase Protein General Information
Alternate Names
FAP, Seprase, SIMP, DPPIV, FAPA
Curated Database and Bioinformatic Data
Gene Symbol	FAP
Entrez Gene ID	2191
Ensemble Gene ID	ENSG00000078098
RefSeq Protein Accession(s)	NP_001278736.1
RefSeq mRNA Accession(s)	NM_001291807.2, NM_004460.4
UniProt ID(s)	Q12884
UniGene ID(s)	Hs.654370
HGNC ID(s)	HGNC:3590
COSMIC ID Link(s)	FAP
KEGG Gene ID(s)	hsa:2191
PharmGKB ID(s)	PA28003
General Description of Recombinant Human FAP / Seprase Protein.
Cell surface glycoprotein serine protease that participates in Extracellular domain matrix degradation and involved in many cellular processes including tissue rodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma mbrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences, on substrate such as alpha-2-antiplasmin SERPINF2 and SPRY2 . Degrade also gelatin, heat-denatured type I collagen, but not native collagen type I and IV, vibronectin, tenascin, laminin, fibronectin, fibrin or casein . Have also dipeptidyl peptidase activity, exhibiting the ability to hydrolyze the prolyl bond two residues from the N-terminus of synthetic dipeptide substrates provided that the penultimate residue is proline, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro . Natural neuropeptide hormones for dipeptidyl peptidase are the neuropeptide Y (NPY), peptide YY (PYY), substance P (TAC1) and brain natriuretic peptide 32 (NPPB) . The plasma mbrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the Extracellular domain matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Plays a role in tissue rodeling during development and wound healing. Participates in the cell invasiveness towards the ECM in malignant melanoma cancers. Enhances tumor growth progression by increasing angiogenesis, collagen fiber degradation and apoptosis and by reducing antitumor response of the immune syst. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner.

Human FAP / Seprase Recombinant Protein Product Attributes

Product Type: Recombinant Protein

Recombinant FAP / Seprase based upon sequence from Human

Host: QP6020 protein expressed in E. coli.

Tag: GST

Protein Construction: A DNA sequence encoding the Homo sapiens (Human) FAP / Seprase, was expressed in the hosts and tags indicated. Please select your host/tag option, above.

Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.

Application Notes: Please contact us for application specific information for QP6020.

Bioactivity Data: Untested

Full Length? Partial (see sequence information for more details).

Expression Region: Leu26 - Asp760

Amino Acid Sequence: LRPSRVHNSE ENTMRALTLK DILNGTFSYK TFFPNWISGQ EYLHQSADNN IVLYNIETGQ SYTILSNRTM KSVNASNYGL SPDRQFVYLE SDYSKLWRYS YTATYYIYDL SNGEFVRGNE LPRPIQYLCW SPVGSKLAYV YQNNIYLKQR PGDPPFQITF NGRENKIFNG IPDWVYEEEM LATKYALWWS PNGKFLAYAE FNDTDIPVIA YSYYGDEQYP RTINIPYPKA GAKNPVVRIF IIDTTYPAYV GPQEVPVPAM IASSDYYFSW LTWVTDERVC LQWLKRVQNV SVLSICDFRE DWQTWDCPKT QEHIEESRTG WAGGFFVSTP VFSYDAISYY KIFSDKDGYK HIHYIKDTVE NAIQITSGKW EAINIFRVTQ DSLFYSSNEF EEYPGRRNIY RISIGSYPPS KKCVTCHLRK ERCQYYTASF SDYAKYYALV CYGPGIPIST LHDGRTDQEI KILEENKELE NALKNIQLPK EEIKKLEVDE ITLWYKMILP PQFDRSKKYP LLIQVYGGPC SQSVRSVFAV NWISYLASKE GMVIALVDGR GTAFQGDKLL YAVYRKLGVY EVEDQITAVR KFIEMGFIDE KRIAIWGWSY GGYVSSLALA SGTGLFKCGI AVAPVSSWEY YASVYTERFM GLPTKDDNLE HYKNSTVMAR AEYFRNVDYL LIHGTADDNV HFQNSAQIAK ALVNAQVDFQ AMWYSDQNHG LSGLSTNHLY THMTHFLKQC FSLSD

Purity: Greater than 90% as determined by SDS-PAGE.

Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.

Concentration of Human FAP / Seprase Protein:

Endotoxin Levels: Not determined.

Buffer: Tris-based buffer, 50% glycerol

Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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