SDS-PAGE separation of QP6075 followed by commassie total protein stain results in a primary band consistent with reported data for GDF5. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Mouse GDF5 Protein

$ 578.00 – $ 2,468.00

Please Select Product Options Below To View The Catalog Number.

SKU: QP6075
Species: Mouse
Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Available Tags: His
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 120

Product Number	Description	Price
QP6075-ec-100ug	Size: 100 ug, Tag: His	$ 578.00
QP6075-ec-1mg	Size: 1 mg, Tag: His	$ 2,468.00

Shipping Information

2-4 weeks

Flat Rate Shipping Anywhere in the US: $45

Datasheets and Documentation

Product Datasheet

Certificate of Analysis and Tags (Coming Soon)

SKU: QP6075-ec-10ug

Recombinant Mouse GDF5 Protein General Information
Curated Database and Bioinformatic Data
Gene Symbol	Gdf5
Entrez Gene ID	14563
Ensemble Gene ID	ENSMUSG00000038259
RefSeq Protein Accession(s)	NP_032135.2
RefSeq mRNA Accession(s)	NM_008109.3
UniProt ID(s)	P43027
UniGene ID(s)	Mm.4744
COSMIC ID Link(s)	Gdf5
KEGG Gene ID(s)	mmu:14563
General Description of Recombinant Mouse GDF5 Protein.
Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction . Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG . Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 . Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes .

Mouse GDF5 Recombinant Protein Product Attributes

Product Type: Recombinant Protein

Recombinant GDF5 based upon sequence from Mouse

Host: QP6075 protein expressed in E. coli.

Tag: His

Protein Construction: A DNA sequence encoding the Mus musculus (Mouse) GDF5, was expressed in the hosts and tags indicated. Please select your host/tag option, above.

Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.

Application Notes: Please contact us for application specific information for QP6075.

Bioactivity Data: Untested

Full Length? Full Length

Expression Region: Ala376 - Arg495

Amino Acid Sequence: APLANRQGKR PSKNLKARCS RKALHVNFKD MGWDDWIIAP LEYEAFHCEG LCEFPLRSHL EPTNHAVIQT LMNSMDPEST PPTCCVPTRL SPISILFIDS ANNVVYKQYE DMVVESCGCR

Purity: Greater than 90% as determined by SDS-PAGE.

Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.

Concentration of Mouse GDF5 Protein:

Endotoxin Levels: Not determined.

Buffer: Tris-based buffer, 50% glycerol

Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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