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Recombinant Human Cell cycle checkpoint protein RAD1 Protein

$ 148.00 – $ 1,728.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP6577
Species: Human
Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Available Tags: GST
Host: E. coli
Purity: Greater than 80% as determined by SDS-PAGE.
Length (Amino Acids): 283

Product NumberDescriptionPrice
QP6577-ec-10ug Size: 10 ug, Tag: GST $ 168.00
QP6577-ec-100ug Size: 100 ug, Tag: GST $ 448.00
QP6577-ec-1mg Size: 1 mg, Tag: GST $ 1,938.00
Shipping Information
2-4 weeks
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP6577-ec-10ug
Recombinant Human Cell cycle checkpoint protein RAD1 Protein General Information
Alternate Names
HRAD1, REC1
Curated Database and Bioinformatic Data
Gene SymbolRAD1
Entrez Gene ID5810
Ensemble Gene IDENSG00000113456
RefSeq Protein Accession(s)NP_002844.1
RefSeq mRNA Accession(s)NM_002853.3
UniProt ID(s)O60671
UniGene ID(s)Hs.38114
HGNC ID(s)HGNC:9806
COSMIC ID Link(s)RAD1
KEGG Gene ID(s)hsa:5810
PharmGKB ID(s)PA34166
General Description of Recombinant Human Cell cycle checkpoint protein RAD1 Protein.
Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. Isoform 1 possesses 3'->5' double stranded DNA exonuclease activity.

Human Cell cycle checkpoint protein RAD1 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant Cell cycle checkpoint protein RAD1 based upon sequence from Human
Host: QP6577 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Cell cycle checkpoint protein RAD1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6577.
Bioactivity Data: Untested
Full Length? Full Length
Amino Acid Sequence: MPLLTQQIQD EDDQYSLVAS LDNVRNLSTI LKAIHFREHA TCFATKNGIK VTVENAKCVQ ANAFIQAGIF QEFKVQEESV TFRINLTVLL DCLSIFGSSP MPGTLTALRM CYQGYGYPLM LFLEEGGVVT VCKINTQEPE ETLDFDFCST NVINKIILQS EGLREAFSEL DMTSEVLQIT MSPDKPYFRL STFGNAGSSH LDYPKDSDLM EAFHCNQTQV NRYKISLLKP STKALVLSCK VSIRTDNRGF LSLQYMIRNE DGQICFVEYY CCPDEEVPES ES
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Cell cycle checkpoint protein RAD1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human Cell cycle checkpoint protein RAD1 Protein