SDS-PAGE separation of QP6627 followed by commassie total protein stain results in a primary band consistent with reported data for 40S ribosomal protein S3. These data demonstrate Greater than 90% as determined by SDS-PAGE.
SDS-PAGE separation of QP6627 followed by commassie total protein stain results in a primary band consistent with reported data for 40S ribosomal protein S3. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Mouse 40S ribosomal protein S3

$ 288.00$ 2,468.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP6627
Species: Mouse
Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Available Tags: His-SUMO
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 242

Product NumberDescriptionPrice
QP6627-ec-10ug Size: 10 ug, Tag: His-SUMO $ 288.00
QP6627-ec-50ug Size: 50 ug, Tag: His-SUMO $ 408.00
QP6627-ec-100ug Size: 100 ug, Tag: His-SUMO $ 708.00
QP6627-ec-200ug Size: 200 ug, Tag: His-SUMO $ 1,158.00
QP6627-ec-500ug Size: 500 ug, Tag: His-SUMO $ 1,548.00
QP6627-ec-1mg Size: 1 mg, Tag: His-SUMO $ 2,468.00
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SKU: QP6627-ec-10ug
Recombinant Mouse 40S ribosomal protein S3 Protein General Information
Alternate Names
S3
Curated Database and Bioinformatic Data
Gene SymbolRPS3
Entrez Gene ID6188
Ensemble Gene IDENSG00000149273
RefSeq Protein Accession(s)NP_000996.2
RefSeq mRNA Accession(s)NM_001005.4, NM_001256802.1, NM_001260506.1, NM_001260507.1
UniProt ID(s)P23396
UniGene ID(s)Hs.546286
HGNC ID(s)HGNC:10420
COSMIC ID Link(s)RPS3
KEGG Gene ID(s)hsa:6188
PharmGKB ID(s)PA34829
General Description of Recombinant Mouse 40S ribosomal protein S3 Protein.
Involved in translation as a component of the 40S small ribosomal subunit (PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408).

Mouse 40S ribosomal protein S3 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant 40S ribosomal protein S3 based upon sequence from Mouse
Host: QP6627 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Mus musculus (Mouse) 40S ribosomal protein S3, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6627.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Ala2 - Ala243
Amino Acid Sequence: AVQISKKRKF VADGIFKAEL NEFLTRELAE DGYSGVEVRV TPTRTEIIIL ATRTQNVLGE KGRRIRELTA VVQKRFGFPE GSVELYAEKV ATRGLCAIAQ AESLRYKLLG GLAVRRACYG VLRFIMESGA KGCEVVVSGK LRGQRAKSMK FVDGLMIHSG DPVNYYVDTA VRHVLLRQGV LGIKVKIMLP WDPTGKIGPK KPLPDHVSIV EPKDEILPTT PISEQKGGKP EPPAMPQPVP TA
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Mouse 40S ribosomal protein S3 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Mouse 40S ribosomal protein S3

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