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Recombinant Human SIRP alpha / CD172a Protein

$ 398.00 – $ 1,728.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP6684
Species: Human
Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Available Tags: His-SUMO
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 343

Product NumberDescriptionPrice
QP6684-ec-100ug Size: 100 ug, Tag: His-SUMO $ 398.00
QP6684-ec-1mg Size: 1 mg, Tag: His-SUMO $ 1,728.00
Shipping Information
2-4 weeks
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP6684-ec-10ug
Recombinant Human SIRP alpha / CD172a Protein General Information
Alternate Names
SIRP alpha, CD172a, Bit, SHPS-1, SIRP, P84, AI835480, SHP-1, CD172a, Ptpns1
Curated Database and Bioinformatic Data
Gene SymbolSIRPA
Entrez Gene ID140885
Ensemble Gene IDENSG00000198053
RefSeq Protein Accession(s)NP_001035111.1
RefSeq mRNA Accession(s)NM_001040022.1, NM_001040023.1, NM_001330728.1, NM_080792.2, XM_005260670.3
UniProt ID(s)P78324
UniGene ID(s)Hs.581021
HGNC ID(s)HGNC:9662
COSMIC ID Link(s)SIRPA
KEGG Gene ID(s)hsa:140885
PharmGKB ID(s)PA34006
General Description of Recombinant Human SIRP alpha / CD172a Protein.
Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma mbrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function . Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

Human SIRP alpha / CD172a Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant SIRP alpha / CD172a based upon sequence from Human
Host: QP6684 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) SIRP alpha / CD172a, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6684.
Bioactivity Data: Untested
Full Length? Extracellular Domain
Expression Region: Glu31 - Tyr373
Amino Acid Sequence: EEELQVIQPD KSVLVAAGET ATLRCTATSL IPVGPIQWFR GAGPGRELIY NQKEGHFPRV TTVSDLTKRN NMDFSIRIGN ITPADAGTYY CVKFRKGSPD DVEFKSGAGT ELSVRAKPSA PVVSGPAARA TPQHTVSFTC ESHGFSPRDI TLKWFKNGNE LSDFQTNVDP VGESVSYSIH STAKVVLTRE DVHSQVICEV AHVTLQGDPL RGTANLSETI RVPPTLEVTQ QPVRAENQVN VTCQVRKFYP QRLQLTWLEN GNVSRTETAS TVTENKDGTY NWMSWLLVNV SAHRDDVKLT CQVEHDGQPA VSKSHDLKVS AHPKEQGSNT AAENTGSNER NIY
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human SIRP alpha / CD172a Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human SIRP alpha / CD172a Protein