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SDS-PAGE separation of QP6697 followed by commassie total protein stain results in a primary band consistent with reported data for Smad3. These data demonstrate Greater than 90% as determined by SDS-PAGE.
SDS-PAGE separation of QP6697 followed by commassie total protein stain results in a primary band consistent with reported data for Smad3. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Human Smad3 Protein

$ 398.00 – $ 1,728.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP6697
Species: Human
Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Available Tags: His-SUMO
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 425

Product NumberDescriptionPrice
QP6697-ec-100ug Size: 100 ug, Tag: His-SUMO $ 448.00
QP6697-ec-1mg Size: 1 mg, Tag: His-SUMO $ 1,938.00
Shipping Information
2-4 weeks
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP6697-ec-10ug
Recombinant Human Smad3 Protein General Information
Alternate Names
Smad3, Smad 3, Madh3, mad3
Curated Database and Bioinformatic Data
Gene SymbolSMAD3
Entrez Gene ID4088
Ensemble Gene IDENSG00000166949
RefSeq Protein Accession(s)NP_001138574.1
RefSeq mRNA Accession(s)NM_001145102.1, NM_001145103.1, NM_001145104.1, NM_005902.3
UniProt ID(s)P84022
UniGene ID(s)Hs.727986
HGNC ID(s)HGNC:6769
COSMIC ID Link(s)SMAD3
KEGG Gene ID(s)hsa:4088
PharmGKB ID(s)PA30526
General Description of Recombinant Human Smad3 Protein.
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE elent in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator

Human Smad3 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant Smad3 based upon sequence from Human
Host: QP6697 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Smad3, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6697.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 - Ser425
Amino Acid Sequence: MSSILPFTPP IVKRLLGWKK GEQNGQEEKW CEKAVKSLVK KLKKTGQLDE LEKAITTQNV NTKCITIPRS LDGRLQVSHR KGLPHVIYCR LWRWPDLHSH HELRAMELCE FAFNMKKDEV CVNPYHYQRV ETPVLPPVLV PRHTEIPAEF PPLDDYSHSI PENTNFPAGI EPQSNIPETP PPGYLSEDGE TSDHQMNHSM DAGSPNLSPN PMSPAHNNLD LQPVTYCEPA FWCSISYYEL NQRVGETFHA SQPSMTVDGF TDPSNSERFC LGLLSNVNRN AAVELTRRHI GRGVRLYYIG GEVFAECLSD SAIFVQSPNC NQRYGWHPAT VCKIPPGCNL KIFNNQEFAA LLAQSVNQGF EAVYQLTRMC TIRMSFVKGW GAEYRRQTVT STPCWIELHL NGPLQWLDKV LTQMGSPSIR CSSVS
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Smad3 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human Smad3 Protein

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