SDS-PAGE separation of QP6735 followed by commassie total protein stain results in a primary band consistent with reported data for STAT3. These data demonstrate Greater than 90% as determined by SDS-PAGE.
SDS-PAGE separation of QP6735 followed by commassie total protein stain results in a primary band consistent with reported data for STAT3. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Human STAT3 Protein

$ 148.00$ 1,678.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP6735
Species: Human
Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Available Tags: His-SUMO
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 191

Size
Tag Clear selection
Shipping Information
2-4 weeks
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
SKU: QP6735-ec-10ug
Recombinant Human STAT3 Protein General Information
Alternate Names
APRF, HIES, ADMIO, ADMIO1, Signal transducer and activator of transcription
Curated Database and Bioinformatic Data
Gene SymbolSTAT3
Entrez Gene ID6774
Ensemble Gene IDENSG00000168610
RefSeq Protein Accession(s)NP_003141.2
RefSeq mRNA Accession(s)NM_003150.3, NM_139276.2, NM_213662.1, XM_005257616.3, XM_005257617.3, XM_011525145.2, XM_011525146.2, XM_017024972.1, XM_017024975.1
UniProt ID(s)P40763
UniGene ID(s)Hs.463059
HGNC ID(s)HGNC:11364
COSMIC ID Link(s)STAT3
KEGG Gene ID(s)hsa:6774
PharmGKB ID(s)PA337
General Description of Recombinant Human STAT3 Protein.
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elents identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic domain STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G .

Human STAT3 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant STAT3 based upon sequence from Human
Host: QP6735 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) STAT3, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6735.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Glu50 - Leu240
Amino Acid Sequence: ESHATLVFHN LLGEIDQQYS RFLQESNVLY QHNLRRIKQF LQSRYLEKPM EIARIVARCL WEESRLLQTA ATAAQQGGQA NHPTAAVVTE KQQMLEQHLQ DVRKRVQDLE QKMKVVENLQ DDFDFNYKTL KSQGDMQDLN GNNQSVTRQK MQQLEQMLTA LDQMRRSIVS ELAGLLSAME YVQKTLTDEE L
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human STAT3 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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