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Recombinant Human Transcription elongation factor SPT4 Protein

$ 228.00$ 2,468.00
Please Select A Product To View The SKU.

SKU: QP6753
Species: Human
Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Available Tags: GST
Host: E. coli
Purity: Greater than 80% as determined by SDS-PAGE.
Length (Amino Acids): 116

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Shipping Information
2-4 weeks
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Datasheets and Documentation
Product Datasheet
SKU: QP6753-ec-10ug
Recombinant Human Transcription elongation factor SPT4 Protein General Information
Alternate Names
SPT4H, SUPT4H, Supt4a, SPT4
Curated Database and Bioinformatic Data
Gene SymbolSUPT4H1
Entrez Gene ID6827
Ensemble Gene IDENSG00000213246
RefSeq Protein Accession(s)NP_003159.1
RefSeq mRNA Accession(s)NM_003168.2
UniProt ID(s)P63272
UniGene ID(s)Hs.439481
HGNC ID(s)HGNC:11467
COSMIC ID Link(s)SUPT4H1
KEGG Gene ID(s)hsa:6827
PharmGKB ID(s)PA36253
General Description of Recombinant Human Transcription elongation factor SPT4 Protein.
Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.

Human Transcription elongation factor SPT4 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant Transcription elongation factor SPT4 based upon sequence from Human
Host: QP6753 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Transcription elongation factor SPT4, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6753.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Ala1 - Thr117
Amino Acid Sequence: ALETVPKDLR HLRACLLCSL VKTIDQFEYD GCDNCDAYLQ MKGNREMVYD CTSSSFDGII AMMSPEDSWV SKWQRVSNFK PGVYAVSVTG RLPQGIVREL KSRGVAYKSR DTAIKT
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Transcription elongation factor SPT4 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human Transcription elongation factor SPT4 Protein