SEQUEST analysis of LC MS/MS spectra obtained from a run with QP6838 identified a match between this protein and the spectra of a peptide sequence that matches a region of TNF receptor-associated factor 6.
SEQUEST analysis of LC MS/MS spectra obtained from a run with QP6838 identified a match between this protein and the spectra of a peptide sequence that matches a region of TNF receptor-associated factor 6.Additional SEQUEST analysis of the LC MS/MS spectra from QP6838 identified an additional between this protein and the spectra of another peptide sequence that matches a region of TNF receptor-associated factor 6 confirming successful recombinant synthesis.

Recombinant Human TNF receptor-associated factor 6 Protein

$ 148.00$ 1,678.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP6838
Species: Human
Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Available Tags: His-SUMO
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 522

Size
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Shipping Information
2-4 weeks
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
SKU: QP6838-ec-10ug
Recombinant Human TNF receptor-associated factor 6 Protein General Information
Alternate Names
MGC:3310, RNF85
Curated Database and Bioinformatic Data
Gene SymbolTRAF6
Entrez Gene ID7189
Ensemble Gene IDENSG00000175104
RefSeq Protein Accession(s)NP_004611.1
RefSeq mRNA Accession(s)NM_004620.3, NM_145803.2
UniProt ID(s)Q9Y4K3
UniGene ID(s)Hs.444172
HGNC ID(s)HGNC:12036
COSMIC ID Link(s)TRAF6
KEGG Gene ID(s)hsa:7189
PharmGKB ID(s)PA36713
General Description of Recombinant Human TNF receptor-associated factor 6 Protein.
E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Ses to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that ses to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production

Human TNF receptor-associated factor 6 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant TNF receptor-associated factor 6 based upon sequence from Human
Host: QP6838 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) TNF receptor-associated factor 6, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6838.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 - Val522
Amino Acid Sequence: MSLLNCENSC GSSQSESDCC VAMASSCSAV TKDDSVGGTA STGNLSSSFM EEIQGYDVEF DPPLESKYEC PICLMALREA VQTPCGHRFC KACIIKSIRD AGHKCPVDNE ILLENQLFPD NFAKREILSL MVKCPNEGCL HKMELRHLED HQAHCEFALM DCPQCQRPFQ KFHINIHILK DCPRRQVSCD NCAASMAFED KEIHDQNCPL ANVICEYCNT ILIREQMPNH YDLDCPTAPI PCTFSTFGCH EKMQRNHLAR HLQENTQSHM RMLAQAVHSL SVIPDSGYIS EVRNFQETIH QLEGRLVRQD HQIRELTAKM ETQSMYVSEL KRTIRTLEDK VAEIEAQQCN GIYIWKIGNF GMHLKCQEEE KPVVIHSPGF YTGKPGYKLC MRLHLQLPTA QRCANYISLF VHTMQGEYDS HLPWPFQGTI RLTILDQSEA PVRQNHEEIM DAKPELLAFQ RPTIPRNPKG FGYVTFMHLE ALRQRTFIKD DTLLVRCEVS TRFDMGSLRR EGFQPRSTDA GV
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human TNF receptor-associated factor 6 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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