SDS-PAGE separation of QP6843 followed by commassie total protein stain results in a primary band consistent with reported data for TRPA1. These data demonstrate Greater than 90% as determined by SDS-PAGE.
SDS-PAGE separation of QP6843 followed by commassie total protein stain results in a primary band consistent with reported data for TRPA1. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Human TRPA1 Protein

$ 228.00$ 2,468.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP6843
Species: Human
Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Available Tags: His-SUMO
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 163

Size
Tag Clear selection
Shipping Information
2-4 weeks
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
SKU: QP6843-ec-10ug
Recombinant Human TRPA1 Protein General Information
Alternate Names
FEPS, ANKTM1, Transient receptor potential cation channel subfamily A member
Curated Database and Bioinformatic Data
Gene SymbolTRPA1
Entrez Gene ID8989
Ensemble Gene IDENSG00000104321
RefSeq Protein Accession(s)NP_015628.2
RefSeq mRNA Accession(s)NM_007332.2, XM_011517625.2, XM_017013946.1
UniProt ID(s)O75762
UniGene ID(s)Hs.716816
HGNC ID(s)HGNC:497
COSMIC ID Link(s)TRPA1
KEGG Gene ID(s)hsa:8989
General Description of Recombinant Human TRPA1 Protein.
Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function (PubMed:25389312, PubMed:25855297). Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, cinnamaldehyde, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes (PubMed:25389312, PubMed:20547126). Is also activated by menthol (in vitro)(PubMed:25389312). Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity).

Human TRPA1 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant TRPA1 based upon sequence from Human
Host: QP6843 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) TRPA1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6843.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Ile957 - Pro1119
Amino Acid Sequence: IGLAVGDIAE VQKHASLKRI AMQVELHTSL EKKLPLWFLR KVDQKSTIVY PNKPRSGGML FHIFCFLFCT GEIRQEIPNA DKSLEMEILK QKYRLKDLTF LLEKQHELIK LIIQKMEIIS ETEDDDSHCS FQDRFKKEQM EQRNSRWNTV LRAVKAKTHH LEP
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human TRPA1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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