SDS-PAGE separation of QP7503 followed by commassie total protein stain results in a primary band consistent with reported data for Fragile histidine triad / FHIT. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Mouse Fragile histidine triad / FHIT Protein

$ 578.00 – $ 2,468.00

Please Select Product Options Below To View The Catalog Number.

SKU: QP7503
Species: Mouse
Available Tags: His
Host: E.coli, Yeast.
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 149

Product Number	Description	Price
QP7503-ec-100ug	Size: 100 ug, Tag: His	$ 578.00
QP7503-ec-1mg	Size: 1 mg, Tag: His	$ 2,468.00
QP7503-ye-100ug	Size: 100 ug, Tag: His	$ 578.00
QP7503-ye-500ug	Size: 500 ug, Tag: His	$ 1,588.00

Shipping Information

On Demand Protein: 3-5 Week Lead Time. (Why?)

Flat Rate Shipping Anywhere in the US: $45

Datasheets and Documentation

Product Datasheet

Certificate of Analysis and Tags (Coming Soon)

SKU: QP7503-ec-10ug

Recombinant Mouse Fragile histidine triad / FHIT Protein General Information
Alternate Names
Fragile histidine triad; FHIT; AP3Aase; FRA3B
Curated Database and Bioinformatic Data
Gene Symbol	Fhit
Entrez Gene ID	14198
Ensemble Gene ID	ENSMUSG00000060579
RefSeq Protein Accession(s)	NP_001295215.1
RefSeq mRNA Accession(s)	NM_001308286.1, NM_010210.3, XM_006517927.3, XM_011244732.2, XM_017315847.1
UniProt ID(s)	O89106
UniGene ID(s)	Mm.397619
COSMIC ID Link(s)	Fhit
KEGG Gene ID(s)	mmu:14198
General Description of Recombinant Mouse Fragile histidine triad / FHIT Protein.
Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extrely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity . Functions as tumor suppressor.

Mouse Fragile histidine triad / FHIT Recombinant Protein Product Attributes

Product Type: Recombinant Protein

Recombinant Fragile histidine triad / FHIT based upon sequence from: Mouse

Host: QP7503 protein expressed in E.coli, Yeast..

Tag: His

Protein Construction: A DNA sequence encoding the Mus musculus (Mouse) Fragile histidine triad / FHIT, was expressed in the hosts and tags indicated. Please select your host/tag option, above.

Application Notes: Please contact us for application specific information for QP7503.

Bioactivity Data: Untested

Full Length? Full Length

Expression Region: Ser2 - Ala150

Amino Acid Sequence: SFRFGQHLIK PSVVFLKTEL SFALVNRKPV VPGHVLVCPL RPVERFRDLH PDEVADLFQV TQRVGTVVEK HFQGTSITFS MQDGPEAGQT VKHVHVHVLP RKAGDFPRND NIYDELQKHD REEEDSPAFW RSEKEMAAEA EALRVYFQA

Purity: Greater than 90% as determined by SDS-PAGE.

Reconstitution Instructions:

Concentration of Mouse Fragile histidine triad / FHIT Protein:

Endotoxin Levels: Not determined.

Buffer: Tris-based buffer, 50% glycerol

Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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