SDS-PAGE separation of QP7971 followed by commassie total protein stain results in a primary band consistent with reported data for Mixed lineage kinase domain-like protein. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Human Mixed lineage kinase domain-like Protein

$ 398.00 – $ 1,728.00

Please Select Product Options Below To View The Catalog Number.

SKU: QP7971
Species: Human
Available Tags: His, His-SUMO
Host: E.coli, Yeast.
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 471

Product Number	Description	Price
QP7971-ye-100ug	Size: 100 ug, Tag: His	$ 468.00
QP7971-ye-500ug	Size: 500 ug, Tag: His	$ 1,298.00
QP7971-ec-100ug	Size: 100 ug, Tag: His-SUMO	$ 398.00
QP7971-ec-1mg	Size: 1 mg, Tag: His-SUMO	$ 1,728.00

Shipping Information

On Demand Protein: 3-5 Week Lead Time. (Why?)

Flat Rate Shipping Anywhere in the US: $45

Datasheets and Documentation

Product Datasheet

Certificate of Analysis and Tags (Coming Soon)

SKU: QP7971-ye-10ug

Recombinant Human Mixed lineage kinase domain-like protein Protein General Information
Alternate Names
hMLKL
Curated Database and Bioinformatic Data
Gene Symbol	MLKL
Entrez Gene ID	197259
Ensemble Gene ID	ENSG00000168404
RefSeq Protein Accession(s)	NP_001135969.1
RefSeq mRNA Accession(s)	NM_001142497.2, NM_152649.3, XM_005255834.3
UniProt ID(s)	Q8NB16
UniGene ID(s)	Hs.119878
HGNC ID(s)	HGNC:26617
COSMIC ID Link(s)	MLKL
KEGG Gene ID(s)	hsa:197259
PharmGKB ID(s)	PA142671349
General Description of Recombinant Human Mixed lineage kinase domain-like protein Protein.
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma mbrane and execution of programmed necrosis characterized by calcium influx and plasma mbrane damage. Does not have protein kinase activity.

Human Mixed lineage kinase domain-like protein Recombinant Protein Product Attributes

Product Type: Recombinant Protein

Recombinant Mixed lineage kinase domain-like protein based upon sequence from: Human

Host: QP7971 protein expressed in E.coli, Yeast..

Tag: His

Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Mixed lineage kinase domain-like protein, was expressed in the hosts and tags indicated. Please select your host/tag option, above.

Application Notes: Please contact us for application specific information for QP7971.

Bioactivity Data: Untested

Full Length? Full Length

Expression Region: Met1 - Lys471

Amino Acid Sequence: MENLKHIITL GQVIHKRCEE MKYCKKQCRR LGHRVLGLIK PLEMLQDQGK RSVPSEKLTT AMNRFKAALE EANGEIEKFS NRSNICRFLT ASQDKILFKD VNRKLSDVWK ELSLLLQVEQ RMPVSPISQG ASWAQEDQQD ADEDRRAFQM LRRDNEKIEA SLRRLEINMK EIKETLRQYL PPKCMQEIPQ EQIKEIKKEQ LSGSPWILLR ENEVSTLYKG EYHRAPVAIK VFKKLQAGSI AIVRQTFNKE IKTMKKFESP NILRIFGICI DETVTPPQFS IVMEYCELGT LRELLDREKD LTLGKRMVLV LGAARGLYRL HHSEAPELHG KIRSSNFLVT QGYQVKLAGF ELRKTQTSMS LGTTREKTDR VKSTAYLSPQ ELEDVFYQYD VKSEIYSFGI VLWEIATGDI PFQGCNSEKI RKLVAVKRQQ EPLGEDCPSE LREIIDECRA HDPSVRPSVD EILKKLSTFS K

Purity: Greater than 90% as determined by SDS-PAGE.

Reconstitution Instructions:

Concentration of Human Mixed lineage kinase domain-like protein Protein:

Endotoxin Levels: Not determined.

Buffer: Tris-based buffer, 50% glycerol

Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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