SDS-PAGE separation of QP8013 followed by commassie total protein stain results in a primary band consistent with reported data for RARRES2 / Chemerin. These data demonstrate Greater than 80% as determined by SDS-PAGE.

Recombinant Human RARRES2 / Chemerin Protein

$ 398.00 – $ 1,728.00

Please Select Product Options Below To View The Catalog Number.

SKU: QP8013
Species: Human
Available Tags: His-SUMO
Host: E. coli
Purity: Greater than 80% as determined by SDS-PAGE.
Length (Amino Acids): 137

Product Number	Description	Price
QP8013-ec-100ug	Size: 100 ug, Tag: His-SUMO	$ 398.00
QP8013-ec-1mg	Size: 1 mg, Tag: His-SUMO	$ 1,728.00

Shipping Information

7-10 days

Flat Rate Shipping Anywhere in the US: $45

Datasheets and Documentation

Product Datasheet

Certificate of Analysis and Tags (Coming Soon)

SKU: QP8013-ec-10ug

Recombinant Human RARRES2 / Chemerin Protein General Information
Alternate Names
TIG2; HP10433
Curated Database and Bioinformatic Data
Gene Symbol	RARRES2
Entrez Gene ID	5919
Ensemble Gene ID	ENSG00000106538
RefSeq Protein Accession(s)	NP_002880.1
RefSeq mRNA Accession(s)	NM_002889.3
UniProt ID(s)	Q99969
UniGene ID(s)	Hs.647064
HGNC ID(s)	HGNC:9868
COSMIC ID Link(s)	RARRES2
KEGG Gene ID(s)	hsa:5919
PharmGKB ID(s)	PA34229
General Description of Recombinant Human RARRES2 / Chemerin Protein.
Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chokine-like receptor 1 (CMKLR1). Its other ligands include G protein-coupled receptor 1 (GPR1) and chokine receptor-like 2 (CCRL2). Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a proinflammatory adipokine, causing an increase in secretion of proinflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells. The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production. Its dual role in inflammation and metabolism might provide a link between chronic inflammation and obesity, as well as obesity-related disorders such as type 2 diabetes and cardiovascular disease. Exhibits an antimicrobial function in the skin

Human RARRES2 / Chemerin Recombinant Protein Product Attributes

Product Type: Recombinant Protein

Recombinant RARRES2 / Chemerin based upon sequence from: Human

Host: QP8013 protein expressed in E. coli.

Tag: His-SUMO

Protein Construction: A DNA sequence encoding the Homo sapiens (Human) RARRES2 / Chemerin, was expressed in the hosts and tags indicated. Please select your host/tag option, above.

Application Notes: Please contact us for application specific information for QP8013.

Bioactivity Data: Untested

Full Length? Full Length

Expression Region: Glu21 - Ser157

Amino Acid Sequence: ELTEAQRRGL QVALEEFHKH PPVQWAFQET SVESAVDTPF PAGIFVRLEF KLQQTSCRKR DWKKPECKVR PNGRKRKCLA CIKLGSEDKV LGRLVHCPIE TQVLREAEEH QETQCLRVQR AGEDPHSFYF PGQFAFS

Purity: Greater than 80% as determined by SDS-PAGE.

Reconstitution Instructions:

Concentration of Human RARRES2 / Chemerin Protein:

Endotoxin Levels: Not determined.

Buffer: Tris-based buffer, 50% glycerol

Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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