Recombinant Human IL1F6 / IL36 Protein

$ 398.00 – $ 1,728.00

Please Select Product Options Below To View The Catalog Number.

SKU: QP8208
Species: Human
Available Tags: GST
Host: E. coli
Purity: Greater than 80% as determined by SDS-PAGE.
Length (Amino Acids): 158

Product Number	Description	Price
QP8208-ec-100ug	Size: 100 ug, Tag: GST	$ 448.00
QP8208-ec-1mg	Size: 1 mg, Tag: GST	$ 1,938.00

Shipping Information

On Demand Protein: 3-5 Week Lead Time. (Why?)

Flat Rate Shipping Anywhere in the US: $45

Datasheets and Documentation

Product Datasheet

Certificate of Analysis and Tags (Coming Soon)

SKU: QP8208-ec-10ug

Recombinant Human IL1F6 / IL36 Protein General Information
Curated Database and Bioinformatic Data
Gene Symbol	Il36a
Entrez Gene ID	27179
Ensemble Gene ID	ENSG00000136694
RefSeq Protein Accession(s)	NP_055255.1
RefSeq mRNA Accession(s)	NM_014440.2, XM_005263639.2, XM_011510965.1, XM_017003806.1
UniProt ID(s)	Q9UHA7
UniGene ID(s)	Hs.278910
HGNC ID(s)	HGNC:15562
COSMIC ID Link(s)	Il36a
KEGG Gene ID(s)	hsa:27179
PharmGKB ID(s)	PA38389
General Description of Recombinant Human IL1F6 / IL36 Protein.
Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by upregulating surface expression of CD83, CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T-cell proliferation. May play a role in proinflammatory effects in the lung.

Human IL1F6 / IL36 Recombinant Protein Product Attributes

Product Type: Recombinant Protein

Recombinant IL1F6 / IL36 based upon sequence from: Human

Host: QP8208 protein expressed in E. coli.

Tag: GST

Protein Construction: A DNA sequence encoding the Homo sapiens (Human) IL1F6 / IL36, was expressed in the hosts and tags indicated. Please select your host/tag option, above.

Application Notes: Please contact us for application specific information for QP8208.

Bioactivity Data: Untested

Full Length? Full Length

Expression Region: Met1 - Phe158

Amino Acid Sequence: MEKALKIDTP QQGSIQDINH RVWVLQDQTL IAVPRKDRMS PVTIALISCR HVETLEKDRG NPIYLGLNGL NLCLMCAKVG DQPTLQLKEK DIMDLYNQPE PVKSFLFYHS QSGRNSTFES VAFPGWFIAV SSEGGCPLIL TQELGKANTT DFGLTMLF

Purity: Greater than 80% as determined by SDS-PAGE.

Reconstitution Instructions:

Concentration of Human IL1F6 / IL36 Protein:

Endotoxin Levels: Not determined.

Buffer: Tris-based buffer, 50% glycerol

Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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