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SDS-PAGE separation of QP8369 followed by commassie total protein stain results in a primary band consistent with reported data for Rho guanine nucleotide exchange factor 7. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Human Rho guanine nucleotide exchange factor 7 Protein

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SKU: QP8369
Species: Human
Available Tags: GST
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 250

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Reconsitution Instructions (Leave Blank if Liquid):

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SKU: QP8369-ec-10ug
Recombinant Human Rho guanine nucleotide exchange factor 7 Protein (1-250aa) General Information
Alternate Names
COOL1; Nbla10314; BETA-PIX; COOL-1; PAK3; P50BP; PIXB; P85; P85COOL1; P50; P85SPR
Curated Database and Bioinformatic Data
Gene SymbolARHGEF7
Entrez Gene ID8874
Ensemble Gene IDENSG00000102606
RefSeq Protein Accession(s)NP_001106983.1
RefSeq mRNA Accession(s)NM_001113511.2, NM_001113512.2, NM_001113513.1, NM_001320851.1, NM_001320853.1, NM_001320854.1, NM_001330597.1, NM_001330598.1, NM_003899.3, NM_145735.3, XM_017020824.1, XM_017020825.1
UniProt ID(s)Q14155
UniGene ID(s)Hs.508738
HGNC ID(s)HGNC:15607
COSMIC ID Link(s)ARHGEF7
KEGG Gene ID(s)hsa:8874
PharmGKB ID(s)PA24977
General Description of Recombinant Human Rho guanine nucleotide exchange factor 7 Protein (1-250aa).
Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce mbrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions . May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.3 Publications

Human Rho guanine nucleotide exchange factor 7 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant Rho guanine nucleotide exchange factor 7 based upon sequence from: Human
Host: QP8369 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Rho guanine nucleotide exchange factor 7, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8369.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 - Pro250
Amino Acid Sequence: MNSAEQTVTW LITLGVLESP KKTISDPEGF LQASLKDGVV LCRLLERLLP GTIEKVYPEP RSESECLSNI REFLRGCGAS LRLELLFPPS QPPQHLVTTI LLSASTFDAN DLYQGQNFNK VLSSLVTLNK VTADIGLGSD SVCARPSSHR IKSFDSLGSQ SLHTRTSKLF QGQYRSLDMT DNSNNQLVVR AKFNFQQTNE DELSFSKGDV IHVTRVEEGG WWEGTLNGRT GWFPSNYVRE VKASEKPVSP
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Rho guanine nucleotide exchange factor 7 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human Rho guanine nucleotide exchange factor 7 Protein