SDS-PAGE separation of QP8568 followed by commassie total protein stain results in a primary band consistent with reported data for TGF-beta 1 / TGFB1. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Human TGF-beta 1 / TGFB1 Protein

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SKU: QP8568
Species: Human
Available Tags: His
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 110

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Datasheets and Documentation

Product Datasheet

Certificate of Analysis and Tags (Coming Soon)

SKU: QP8568-ec-10ug

Recombinant Human TGF-beta 1 / TGFB1 Protein General Information
Alternate Names
TGF-beta 1; TGFB1; TGF-beta1; Tgfb; Tgfb-1; TGFbeta1
Curated Database and Bioinformatic Data
Gene Symbol	TGFB1
Entrez Gene ID	7040
Ensemble Gene ID	ENSG00000105329
RefSeq Protein Accession(s)	NP_000651.3
RefSeq mRNA Accession(s)	NM_000660.6
UniProt ID(s)	P01137
UniGene ID(s)	Hs.645227
HGNC ID(s)	HGNC:11766
COSMIC ID Link(s)	TGFB1
KEGG Gene ID(s)	hsa:7040
PharmGKB ID(s)	PA350
General Description of Recombinant Human TGF-beta 1 / TGFB1 Protein.
Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone rodeling as it is a potent stimulator of osteoblastic bone formation, causing chotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells.

Human TGF-beta 1 / TGFB1 Recombinant Protein Product Attributes

Product Type: Recombinant Protein

Recombinant TGF-beta 1 / TGFB1 based upon sequence from: Human

Host: QP8568 protein expressed in E. coli.

Tag: His

Protein Construction: A DNA sequence encoding the Homo sapiens (Human) TGF-beta 1 / TGFB1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.

Application Notes: Please contact us for application specific information for QP8568.

Bioactivity Data: Untested

Full Length? Partial (see sequence information for more details).

Expression Region: Asp279 - Ser390

Amino Acid Sequence: DTNYCFSSTE KNCCVRQLYI DFRKDLGWKW IHEPKGYHAN FCLGPCPYIW SLDTQYSKVL ALYNQHNPGA SAAPCCVPQA LEPLPIVYYV GRKPKVEQLS NMIVRSCKCS

Purity: Greater than 90% as determined by SDS-PAGE.

Reconstitution Instructions:

Concentration of Human TGF-beta 1 / TGFB1 Protein:

Endotoxin Levels: Not determined.

Buffer: Tris-based buffer, 50% glycerol

Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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