SDS-PAGE separation of QP8573 followed by commassie total protein stain results in a primary band consistent with reported data for TNF-alpha. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Human TNF-alpha Protein

$ 88.00 – $ 1,138.00

Please Select Product Options Below To View The Catalog Number.

SKU: QP8573
Species: Human
Available Tags: His
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 157

Product Number	Description	Price
QP8573-ec-10ug	Size: 10 ug, Tag: His	$ 88.00
QP8573-ec-50ug	Size: 50 ug, Tag: His	$ 198.00
QP8573-ec-100ug	Size: 100 ug, Tag: His	$ 268.00
QP8573-ec-200ug	Size: 200 ug, Tag: His	$ 368.00
QP8573-ec-500ug	Size: 500 ug, Tag: His	$ 738.00
QP8573-ec-1mg	Size: 1 mg, Tag: His	$ 1,138.00

Shipping Information

On Demand Protein: 3-5 Week Lead Time. (Why?)

Flat Rate Shipping Anywhere in the US: $45

Datasheets and Documentation

Product Datasheet

Certificate of Analysis and Tags (Coming Soon)

SKU: QP8573-ec-10ug

Recombinant Human TNF-alpha Protein General Information
Alternate Names
TNF-alpha; TNF-a; Cachectin; TNFSF2; TNF-alpha; TNFA
Curated Database and Bioinformatic Data
Gene Symbol	TNF
Entrez Gene ID	7124
Ensemble Gene ID	ENSG00000204490
RefSeq Protein Accession(s)	NP_000585.2
RefSeq mRNA Accession(s)	NM_000594.3
UniProt ID(s)	P01375
UniGene ID(s)	Hs.241570
HGNC ID(s)	HGNC:11892
COSMIC ID Link(s)	TNF
KEGG Gene ID(s)	hsa:7124
PharmGKB ID(s)	PA435
General Description of Recombinant Human TNF-alpha Protein.
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective .

Human TNF-alpha Recombinant Protein Product Attributes

Product Type: Recombinant Protein

Recombinant TNF-alpha based upon sequence from: Human

Host: QP8573 protein expressed in E. coli.

Tag: His

Protein Construction: A DNA sequence encoding the Homo sapiens (Human) TNF-alpha, was expressed in the hosts and tags indicated. Please select your host/tag option, above.

Application Notes: Please contact us for application specific information for QP8573.

Bioactivity Data: Untested

Full Length? Partial (see sequence information for more details).

Expression Region: Val77 - Leu2

Amino Acid Sequence: VRSSSRTPSD KPVAHVVANP QAEGQLQWLN RRANALLANG VELRDNQLVV PSEGLYLIYS QVLFKGQGCP STHVLLTHTI SRIAVSYQTK VNLLSAIKSP CQRETPEGAE AKPWYEPIYL GGVFQLEKGD RLSAEINRPD YLDFAESGQV YFGIIAL

Purity: Greater than 90% as determined by SDS-PAGE.

Reconstitution Instructions:

Concentration of Human TNF-alpha Protein:

Endotoxin Levels: Not determined.

Buffer: Tris-based buffer, 50% glycerol

Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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