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SDS-PAGE separation of QP8786 followed by commassie total protein stain results in a primary band consistent with reported data for AGER / RAGE. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Human AGER / RAGE Protein

$ 398.00 – $ 1,728.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP8786
Species: Human
Available Tags: His
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 320

Product NumberDescriptionPrice
QP8786-ec-100ug Size: 100 ug, Tag: His $ 398.00
QP8786-ec-1mg Size: 1 mg, Tag: His $ 1,728.00
Shipping Information
On Demand Protein: 3-5 Week Lead Time. (Why?)
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP8786-ec-10ug
Recombinant Human AGER / RAGE Protein General Information
Alternate Names
AGER; RAGE; SCARJ1; RAGE
Curated Database and Bioinformatic Data
Gene SymbolAGER
Entrez Gene ID177
Ensemble Gene IDENSG00000204305
RefSeq Protein Accession(s)NP_001127.1
RefSeq mRNA Accession(s)NM_001136.4, NM_001206929.1, NM_001206932.1, NM_001206934.1, NM_001206936.1, NM_001206940.1, NM_001206954.1, NM_001206966.1, NM_172197.2
UniProt ID(s)Q15109
UniGene ID(s)Hs.534342
HGNC ID(s)HGNC:320
COSMIC ID Link(s)AGER
KEGG Gene ID(s)hsa:177
PharmGKB ID(s)PA24617
General Description of Recombinant Human AGER / RAGE Protein.
Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling . Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell mbrane from the Extracellular domain to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport syst delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.4 Publications

Human AGER / RAGE Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant AGER / RAGE based upon sequence from: Human
Host: QP8786 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) AGER / RAGE, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8786.
Bioactivity Data: Untested
Full Length? Extracellular Domain
Expression Region: Ala23 - Ala342
Amino Acid Sequence: AQNITARIGE PLVLKCKGAP KKPPQRLEWK LNTGRTEAWK VLSPQGGGPW DSVARVLPNG SLFLPAVGIQ DEGIFRCQAM NRNGKETKSN YRVRVYQIPG KPEIVDSASE LTAGVPNKVG TCVSEGSYPA GTLSWHLDGK PLVPNEKGVS VKEQTRRHPE TGLFTLQSEL MVTPARGGDP RPTFSCSFSP GLPRHRALRT APIQPRVWEP VPLEEVQLVV EPEGGAVAPG GTVTLTCEVP AQPSPQIHWM KDGVPLPLPP SPVLILPEIG PQDQGTYSCV ATHSSHGPQE SRAVSISIIE PGEEGPTAGS VGGSGLGTLA
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human AGER / RAGE Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human AGER / RAGE Protein