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Recombinant Human C-X-C chemokine receptor type 4 Protein

$ 3,478.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP9950
Species: Human
Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Available Tags: His-SUMO
Host: Invitro-E.coli
Purity: Greater than 80% as determined by SDS-PAGE.
Length (Amino Acids): 352

Product NumberDescriptionPrice
QP9950-iv-100ug Size: 100 ug, Tag: His-SUMO
Shipping Information
3-4 weeks
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP9950-iv-10ug
Recombinant Human C-X-C chemokine receptor type 4 Protein General Information
Alternate Names
HSY3RR; FB22; HM89; LAP-3; NPYY3R; WHIM; CD184; LAP3; LESTR; WHIMS; D2S201E; NPY3R; NPYRL; LCR1; NPYR
Curated Database and Bioinformatic Data
Gene SymbolCXCR4
Entrez Gene ID7852
Ensemble Gene IDENSG00000121966
RefSeq Protein Accession(s)NP_001008540.1
RefSeq mRNA Accession(s)NM_001008540.2, NM_001348056.1, NM_001348059.1, NM_001348060.1, NM_003467.2
UniProt ID(s)P61073
UniGene ID(s)Hs.593413
HGNC ID(s)HGNC:2561
COSMIC ID Link(s)CXCR4
KEGG Gene ID(s)hsa:7852
PharmGKB ID(s)PA27058
General Description of Recombinant Human C-X-C chemokine receptor type 4 Protein.
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival.10 Publications (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) for human immunodeficiency virus-1/HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus (PubMed:9427609, PubMed:10074122, PubMed:10756055). Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205)

Human C-X-C chemokine receptor type 4 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant C-X-C chemokine receptor type 4 based upon sequence from Human
Host: QP9950 protein expressed in Invitro-E.coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) C-X-C chemokine receptor type 4, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP9950.
Bioactivity Data: Untested
Full Length? Full Length Transmembrane Protein
Expression Region: Met1 - Ser352
Amino Acid Sequence: MEGISIYTSD NYTEEMGSGD YDSMKEPCFR EENANFNKIF LPTIYSIIFL TGIVGNGLVI LVMGYQKKLR SMTDKYRLHL SVADLLFVIT LPFWAVDAVA NWYFGNFLCK AVHVIYTVNL YSSVLILAFI SLDRYLAIVH ATNSQRPRKL LAEKVVYVGV WIPALLLTIP DFIFANVSEA DDRYICDRFY PNDLWVVVFQ FQHIMVGLIL PGIVILSCYC IIISKLSHSK GHQKRKALKT TVILILAFFA CWLPYYIGIS IDSFILLEII KQGCEFENTV HKWISITEAL AFFHCCLNPI LYAFLGAKFK TSAQHALTSV SRGSSLKILS KGKRGGHSSV STESESSSFH SS
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human C-X-C chemokine receptor type 4 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human C-X-C chemokine receptor type 4 Protein