Human Anti-AKT1 (Prognostic Marker for Neuroendocrine Tumors) Antibody Product Attributes
Species: Human
Tested Applications: IHC.
Clonality: Monoclonal
Anti-AKT1 (Prognostic Marker for Neuroendocrine Tumors) Antibody Clone: AKT1/2552
Clone AKT1/2552 Host and Isotype: Mouse IgG2b, kappa
Anti-Human AKT1 (Prognostic Marker for Neuroendocrine Tumors) Positive Control Sample: PDGF-treated NIH/3T3 cells. HeLa cell lysates. Human pancreas or cervical carcinoma.
Cellular Localization of Antibody AKT1/2552 Staining: Nuclear, Cytoplasmic and Cell Surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant fragment of human AKT1 protein (apprx. aa 85-189) (Please call for additional information.)
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.
AKT1 (Prognostic Marker for Neuroendocrine Tumors) Previously Observed Antibody Staining Patterns
AKT1 (Prognostic Marker for Neuroendocrine Tumors) General Information | |
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Alternate Names | |
AKT1; Oncogene AKT1; PKB; PKB-ALPHA; PRKBA; Protein Kinase B Alpha; Proto-oncogene c-Akt; RAC Alpha; RAC Serine/Threonine Protein Kinase; RAC-alpha serine/threonine-protein kinase; RAC-PK-alpha | |
Molecular Weight | |
62kDa | |
Chromosomal Location | |
Ships on blue ice. | |
Curated Database and Bioinformatic Data | |
Gene Symbol | 207 |
Entrez Gene ID | AKT1 |
UniProt ID(s) | P31749 |
UniGene ID(s) | Hs525622 |
COSMIC ID Link(s) | AKT1 |
KEGG Gene ID(s) | hsa:207 |
General Description of AKT1 (Prognostic Marker for Neuroendocrine Tumors). | |
Recognizes a protein of 62kDa, which is identified as AKT1. The serine/threonine kinase Akt family contains several members, including Akt1 (also designated PKB or RacPK), Akt2 (also designated PKBβ or RacPK-β) and Akt 3 (also designated PKBγ or thymoma viral proto-oncogene 3), which exhibit sequence homology with the protein kinase A and C families and are encoded by the c-Akt proto-oncogene. All members of the Akt family have a Pleckstrin homology domain. Akt1 and Akt2 are activated by PDGF stimulation. This activation is dependent on PDGFR-β tyrosine residues 740 and 751, which bind the subunit of the phosphatidylinositol 3-kinase (PI 3-kinase) complex. Activation of Akt1 by insulin or insulin-growth factor-1 (IGF-1) results in phosphorylation of both Thr 308 and Ser 473. Akt proteins become phosphorylated and activated in insulin/IGF-1-stimulated cells by an upstream kinase(s), and the activation of Akt1 and Akt2 is inhibited by the PI kinase inhibitor wortmannin. |
Limitations and Warranty
enQuire Bio’s product, AKT1 (Prognostic Marker for Neuroendocrine Tumors) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.
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