.jpg "Adipophilin Perilipin-2 IHC Human Adrenal (ADFP 1366)")
PDF DatasheetHuman Anti-Adipophilin / Perilipin-2 Antibody Product Attributes
Adipophilin / Perilipin-2 Previously Observed Antibody Staining Patterns
Observed Subcellular, Organelle Specific Staining Data:
Anti-PLIN2 antibody staining is expected to be primarily localized to the lipid droplets.
Observed Antibody Staining Data By Tissue Type:
Variations in Adipophilin / Perilipin-2 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in glandular cells in the adrenal gland, lactating glandular cells in the lactating breast, trophoblastic cells in the placenta and glandular cells in the small intestine. More moderate antibody staining intensity was present in glandular cells in the adrenal gland, lactating glandular cells in the lactating breast, trophoblastic cells in the placenta and glandular cells in the small intestine. Low, but measureable presence of Adipophilin / Perilipin-2 could be seen inrespiratory epithelial cells in the bronchus, endothelial cells in the cerebral cortex, glandular cells in the endometrium and epididymis, cells in the tubules in kidney, hepatocytes in liver, glandular cells in the rectum and stomach and Leydig cells in the testis. We were unable to detect Adipophilin / Perilipin-2 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
Observed Antibody Staining Data By Tissue Disease Status:
Tissues from cancer patients, for instance, have their own distinct pattern of Adipophilin / Perilipin-2 expression as measured by anti-Adipophilin / Perilipin-2 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.
| Sample Type | breast cancer | carcinoid | cervical cancer | colorectal cancer | endometrial cancer | glioma | head and neck cancer | liver cancer | lung cancer | lymphoma | melanoma | ovarian cancer | pancreatic cancer | prostate cancer | renal cancer | skin cancer | stomach cancer | testicular cancer | thyroid cancer | urothelial cancer |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal Intensity | + | – | – | ++ | – | – | – | ++ | – | – | + | – | – | – | +++ | – | – | ++ | + | ++ |
| PLIN2 Variability | ++ | ++ | ++ | ++ | ++ | ++ | + | ++ | ++ | + | +++ | ++ | + | ++ | ++ | ++ | ++ | +++ | ++ | +++ |
| Adipophilin / Perilipin-2 General Information | |
|---|---|
| Alternate Names | |
| Lipoprotein-associated phospholipase A2, Lp-PLA2, platelet-activating factor acetylhydrolase, PAF-AH, PLA2G7 | |
| Molecular Weight | |
| 48kDa | |
| Chromosomal Location | |
| 9p22.1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PLIN2 |
| Entrez Gene ID | 123 |
| Ensemble Gene ID | ENSG00000147872 |
| RefSeq Protein Accession(s) | NP_001113, XP_016869748 |
| RefSeq mRNA Accession(s) | NR_038064, XM_017014259, NM_001122 |
| RefSeq Genomic Accession(s) | NC_000009, NC_018920 |
| UniProt ID(s) | Q6FHZ7, Q99541 |
| UniGene ID(s) | Q6FHZ7, Q99541 |
| HGNC ID(s) | 248 |
| Cosmic ID(s) | PLIN2 |
| KEGG Gene ID(s) | hsa:123 |
| PharmGKB ID(s) | PA24569 |
| General Description of Adipophilin / Perilipin-2. | |
| Recognizes a protein of 48kDa, which is identified as Adipophilin. It belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. | |
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